Aptamer and Inorganic Nanocarrier Coupling Service

Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization.

CD Bioparticles provide a customized service for coupling aptamers with inorganic nanocarriers for targeted drug delivery. In recent years, new inorganic nanomaterials are emerging as potential candidates for nanocarriers, showing talent in terms of drug-carrying capacity, stability, and biocompatibility. Our experienced scientists have created a comprehensive technical service to design upon request aptamers for drug delivery coupled to inorganic nanocarriers.

Aptamer and Inorganic Nanocarrier Coupling Service Background

Aptamers are considered to be chemical antibodies that can be easily coupled to drugs, sensors, signal enhancers, or nanocarriers for functionalization and can be flexibly coupled to various nanocarriers by various coupling methods.

In recent years, inorganic materials as nanocarriers have shown great potential for use in drug delivery systems. As the backbone of the system nanocarriers can carry and release drugs, keep the backbone intact during circulation and have good biocompatibility and pharmacological properties. The most commonly studied inorganic nanocarriers are mesoporous silica nanoparticles (MSNs), graphene oxide (GO), black phosphorus (BP), and gold nanoparticles (GNPs). Even some nanomedicines based on inorganic nanocarriers are being evaluated clinically.

Fig. 1 Inorganic nanocarriers. (Shi Z, et al., 2020)

Our Aptamer and Inorganic Nanocarrier Coupling Services

CD Bioparticles specializes in developing drug-targeted delivery aptamers and uses our core technology to enable coupling services between aptamers and inorganic nanocarriers. With our high-quality services, you can significantly improve the progress of your experimental studies.

Our team can provide services from aptamer screening to aptamer-inorganic nanocarrier coupling, and can tailor experimental protocols and services to meet your needs. The aptamer-inorganic nanocarrier delivery systems we offer include, but are not limited to, the following

• Aptamer-Mesoporous Silica Nanoparticles (MSNS) Drug Delivery System

• Aptamer-Graphene Oxide (GO) Drug Delivery System

• Aptamer-Gold Nanoparticles (GNPS) Drug Delivery System

• Aptamer-Copper Nanoparticles (Cu NPS) Drug Delivery System

In addition, properties of the particles such as molecular weight, surface charge and charge density, solubility, and hydrophobicity can be designed to suit your needs.

Our Coupling Service Strengths

• Highly Targeted: Aptamer-coupled inorganic nanomaterials have bioimaging potential and exhibit excellent photothermal therapeutic efficacy against tumor cells in a specific manner.
• Specificity: The service can facilitate research into specific and controlled therapies based on inorganic nanomaterials. A targeted photodynamic therapy (PDT) and photothermal therapy (PTT) reagent has been developed by coupling an aptamer to an inorganic nanomaterial.
• Synergistic Therapy: Aptamer-inorganic nanomaterial coupling allows for easy synergistic anti-cancer treatment with drugs by encapsulating the combined therapeutic agent.
• Image Guided Therapy: Aptamer coupling to inorganic nanocarriers enables imaging-guided therapy and can also be used as Raman signals for cellular imaging purposes, demonstrating the feasibility of traceable anticancer applications.

Contact Us

CD Bioparticles has many years of experience in aptamer development and research, and our scientists are confident that we can provide you with a quality service for coupling aptamers to inorganic nanocarriers to facilitate the development of drug targeting delivery studies. If you are interested in our services, please do not hesitate to contact us for more detailed information.

Quotations and Ordering

Reference

1. Shi Z, Zhou Y, Fan T, et al. Inorganic nano-carriers based smart drug delivery systems for tumor therapy. Smart Materials in Medicine, 2020, 132-47.