Animal Models Evaluation

CD Bioparticles is a company specializing in drug delivery research, with advanced equipment and professional technical personnel. They are familiar with a variety of animal model construction, as well as being able to provide analytical support for Non-GLP or GLP mammalian toxicology.

Introduction to Animal Models Evaluation

Animal disease models are mainly used in the study of physiology, pathology, toxicology, pharmacology and pharmacokinetics. With the help of animal models to simulate human diseases, the results of experiments can be more accurately described. CD Bioparticles is an expert in the field of drug delivery, familiar with various types of drug delivery modes in vivo, and can recommend the most suitable mode of drug delivery in animal models (e.g., oral, intravenous, intramuscular, intraperitoneal subcutaneous) according to the physicochemical properties of the drug. Our laboratory is equipped with advanced laboratory equipment such as NMR, ICP-MS, GC-MS, potentiometric titrator, fully automated blood biochemistry, Leica paraffin embedder, McAuldie biomicroscope, Olympus pathology slide scanner, confocal laser scanning microscope (CLSM), TEM, SEM, MRI, PET, CT and other large-scale instruments, which providing fast turnaround of data and reports for both GLP and Non-GLP projects. We are capable of performing experiments related to animal models, such as animal behavioural studies, histopathology, blood analysis, in vivo pharmacokinetic studies, animal imaging studies, etc., to study the in vivo effects of drugs, so as to accelerate the cclinical translation and registration of the drug.

Figure 1. Pictures of the contents of some animal experiments.

Advantages of Animal Models Evaluation

• Extensive resources and experience to meet your GLP and Non-GLP needs
• Experienced laboratory personnel, familiar with various drug delivery methods and biological sample handling operations
• One-stop service: we can provide all processes from animal modeling to project testing
• Professional personnel to provide solutions, providing you with the most reasonable and economical solutions

Our Featured Services

CD Bioparticles has a full range of leading experts in animal experimentation. We can offer you a wide range of services related to animal experiments:

1. Route of Administration Studies

Providing oral, intravenous, intramuscular, intraperitoneal subcutaneous and other delivery options.

2. Animal Behavioural Studies

Providing learning memory behavioral experiments, emotional behavioral experiments and motor behavior experiments.

3. Animal Histopathological Studies

Providing tissue staining, immunofluorescence and other analyses.

4. Routine Blood Analysis Studies

Providing red blood cell count (RBC), haemoglobin (Hb), white blood cell (WBC), white blood cell count, and platelet (PLT) testing.

5. In Vivo Pharmacokinetic Studies

Providing bioanalytical PK, PD, TK and bioequivalence studies.

6. Animal Imaging Studies

Two techniques, bioluminescence and fluorescence are used for in vivo imaging of mice. Bioluminescence uses the Luciferase gene to label cells or DNA, while fluorescence uses fluorescent reporter groups (GFP, RFP, Cyt and dyes, etc.) for labelling. The labelling methods are highly selective.

Quotations and Ordering

Reference

1. Lian Y, et al.; A biocompatible nano-barium sulfonate system for quad-modal imaging-guided photothermal radiotherapy of tumors. Biomaterials Science. 2023, 11: 4907-4915.