Porous Organic Frameworks (POFs) and Drug Load Customization

CD Bioparticles is a supplier specializing in the research of Porous Organic Frameworks (POFs). CD Bioparticles has an experienced and professional R&D team and state-of-the-art laboratory equipment to develop POFs with different pore sizes, dimensions and types. We can provide customized design services to produce novel POFs according to customer requirements.

Introduction to Porous Organic Frameworks (POFs)

Porous organic framework materials are mainly formed by the self-assembly of metal ions or metal clusters with organic ligands through ligand-binding. They are usually classified as metal-organic frameworks (MOFs), covalent organic frameworks (COFs) and hydrogen-bonded organic frameworks (HOFs). POFs is a new kind of porous material with excellent properties such as high specific surface area, adjustable pore size and pore volume, which is widely used in the fields of gas separation, chemical sensing, environmental remediation, energy storage and drug delivery. POFs Customization can be adjusted in size, pore size, functional groups and the ratio of multi-ligand and multi-metal ions according to the customer's requirements to produce single-type MOFs and hybrid MOFs (e.g. Ni/Co-MOF and Cu/Zn-MOF) with high novelty. Notably, in the field of drug delivery, this customised product can achieve high loading capacity for different types of drugs by adjusting the pore size and optimizing the metal ion formulation ratio. Surface multi-functionalization modifications can also help you to modify other functional molecules such as targeted protein molecules in the next step. CD Bioparticles can help you to improve the performance and efficiency of your products and thus achieve a competitive advantage in terms of product differentiation.

Figure 1. Bimetallic Cu/ZIF-8 MOF material enables gene therapy and in vivo autogenous treatment with chemotherapeutic agents.^[1]

Advantages of POFs Customization

• Individual Customization
  POFs Customization can be carried out according to customers' needs and design concepts to achieve product differentiation and competitive advantage. Customized POFs, especially hybrid POFs, can achieve loading of different drug molecules (hydrophilic drugs, hydrophobic drugs, fluorescent molecules), controllable drug loading, adjustable particle size or surface functionalization modification of polymers (Improved targeting ability and biocompatibility, etc.)
• Quality Assurance
  POFs customized products undergo strict quality control and testing to ensure stable and reliable product quality
• Product Diversity
  POFs has a wide range of customized products and a professional team to guide your experiments
• Fast Delivery
  POFs customized products have the advantage of quick delivery, which can better meet the urgent needs of customers

The Applications of POFs Customization

• Gas Adsorption
• Drug Delivery
• Energy Storage
• Sensors
• Metal Catalysis
• Environmental Remediation

Our Featured Services

CD Bioparticles' professional experimental team can provide customized products and services for researchers and groups working on POFs scenarios and industrialisation worldwide.

Quotations and Ordering

Reference

1. Wang Z, et al.; A Bimetallic Metal-Organic Framework Encapsulated with DNAzyme for Intracellular Drug Synthesis and Self-Sufficient Gene Therapy. Angew. Chem. Int. Ed. 2021, 60, 2-9.