Lipid Library Development for Drug Delivery

• Organelle & Cell & Tissue Targeting Liposomes Formulation and Development
• Lipid Nanoparticle Formulation and Development for mRNA Vaccine Delivery
• Barcoded nanoparticles (NPs) development for high-throughput in vivo analysis
• Antimicrobial Lipid Nanoparticles Formulation, Development, and Function Evaluation

Lipid library development is a crucial aspect of pharmaceutical research, aimed at identifying lipids that can effectively deliver drugs to their target site while minimizing toxicity. At CD Bioparticles, we offer a comprehensive lipid library development service that provides our clients with access to high-quality lipid libraries for drug delivery applications.

The challenges you might meet:

• Difficulty selecting the right lipid for a specific drug delivery system
• Synthesis of specific lipids is time consuming and costly
• The ability, stability, toxicity and targeting efficiency of lipid-encapsulated drugs cannot be evaluated more accurately.
• The work of identifying lipids present in lipid libraries, determining their purity, and assessing their physicochemical properties is complex
• Lack of conditions for mass production of lipids for drug delivery

Lipid Library Development Key Features:

• Antimicrobial Lipid Nanoparticles Formulation, Development, and Function Evaluation
  • Antibiotics delivery via lipid nanoparticles could result in a localized high concentration of the drug can be generated at the site of infection.
  • LNPs themselves, or in combination with a light source, can act as antimicrobial agents against resistant pathogens
  • Robust preparation methods
• Barcoded nanoparticles (NPs) development for high-throughput in vivo analysis
  • DNA barcodes are encapsulated into the NPs instead of tagging on the surface
  • Barcodes provide no biological functions so that it would be able to disturb the particle function
  • Uniform NPs could be collected due to the uniform size of DNA oligonucleotides and applicable formulation strategy (e.g. rapid microfluidic mixing system)
  • Thousands of NPs could be formulated at a single time to generate a large pool for analysis
  • Readouts are presented in a quantitative form via feasible and efficient approaches such as RT-PCR or sequencing

• Lipid Nanoparticle Formulation and Development for mRNA Vaccine Delivery
  • LNP encapsulated mRNA vaccine can be delivered to the cytosol efficiently
  • DC cells targeting is essential for mRNA-LNP vaccines
  • Particle size is the key parameter that determines the LNP accumulation in DCs
  • LNP can be designed to target the DCs via chemical modification or ligand conjugation
  • Adjuvants can be incorporated in LNPs to assist in immune activation
  • LNP synthesis/formulation (e.g. microfluidic device) is robust and upscalable
• Organelle & Cell & Tissue Targeting Liposomes Formulation and Development
  • Passive targeting by size & active targeting by surface modification
  • 3 Main methods to achieve surface modification:
    • Binding the desired targeting ligand to a lipid prior to mixing them with other lipid components during liposome preparation;
    • Liposome are functionalized with the required targeting ligand immediately after preparation;
    • Postinsertion of the functionalized lipid in preformed liposomes

Lipid Library Development Key Features:

Improve Drug Efficacy: We offer lipid library development services to help you find the best lipids for delivering drugs. This can make the treatment more effective and improve the chances of success for your patients.

Custom Solutions: We know that each drug delivery situation is unique, so we work closely with you to create custom lipid libraries that fit your specific needs. This ensures that you receive a tailored solution that works best for your drug delivery requirements.

Expert Guidance: Our expert team has extensive knowledge and expertise in lipid library development and drug delivery. We can provide guidance and advice throughout the process to help you make informed decisions and achieve the best possible outcome.

Advanced Techniques: Our expert team utilizes advanced technology such as chemical synthesis, self-assembly, and microfluidics to create and optimize lipid libraries. During this process, we employ advanced techniques to precisely control the size, charge, and other properties of the lipids. These enables us to provide the suited lipid libraries.

High-Throughput Screening: We use high-throughput screening techniques to get the best lipids for specific drug delivery. These techniques allow us to rapidly assess the availability and toxicity of lipids in the library, thereby reducing the risk of drug development.

Quality Control: We have strict quality control processes in place to ensure our lipid libraries meet the highest standards. This includes extensive testing and analysis to verify the identity, purity and physicochemical properties of the lipids in our library, giving you complete confidence in the quality of our services.

Competitive Prices: We know cost is an important factor and we strive to provide affordable solutions without compromising quality. Our competitive pricing means you get high-quality lipid library development services without breaking the bank.

If you don't see what you need, or don't know what you need, please contact us and our team will work with you to find the right solution for your analysis.