Peptide-Nanoparticles Conjugates Services

Peptide-nanoparticle conjugates are a new material composed of natural and synthetic structural units. By fusing the unique properties of peptides and nanoparticles, new attractive material properties are formed. CD Bioparticles is committed to the field of peptide-nanoparticle conjugates, providing excellent and pragmatic research services. We have outstanding scientists and an experienced technical team, and have created an advanced platform dedicated to the R&D and manufacturing of peptide-nanoparticle conjugate products.

Introduction to Peptide-Nanoparticles Conjugates

Peptide-nanoparticle conjugates belong to a class of promising soft materials because of their unique properties due to the synergy among their components. Among them, peptide is a material that can self-assemble into a natural structure encoded by the primary sequence, so it can support a variety of complex structural functions. These peptide composites exhibit hierarchical self-assembly on multiple different length scales, covering molecular-level structure, chemical reaction function, selectivity and specificity, and dynamic response to external stimuli. These properties are exactly what materials science is concerned with. However, the inherent limitations of biomolecules, such as sensitivity to temperature, pH, organic solvents, and degradation, limit their practical applications. Therefore, coupling the molecular hierarchy and chemical functionality of peptides with stable and processable nanoparticles has the potential to create highly complex and highly modular materials. In fact, peptide-based block copolymers have been intensively studied, and these copolymers can self-assemble into micelles and vesicles, especially in the fields of catalysis and drug delivery.

Figure 1. Combination of artificial bioactive peptides with nanoparticles for biomedical applications.Figure 1. Discovery of artificial bioactive peptides and their conjugation with nanoparticles for biomedical applications. (Jeong WJ, et al.; 2018)

Unlike traditional synthetic nanoparticles, peptide sequences can interact with each other through various supramolecular interactions, such as hydrogen bonding and π-π stacking. The peptide-nanoparticle composites are capable of hierarchical self-organization on at least three different length scales. Most peptide sequences can fold to form secondary structures at the smallest length scales, while some peptides can form tertiary structures depending on the sequence. Finally, microphase separation between peptides and synthetic nanoparticles provides organization on larger length scales. These attractive properties provide additional opportunities to control the self-assembly of peptide-based copolymers and create many unique structures. Such hybrid materials may lead to novel structures and functions for a wide range of biological and abiotic applications.

The specific features of peptide-nanoparticles conjugates include:

  • Targeting ability: By attaching targeting peptides to nanoparticles, the conjugates are able to localize to desired locations, such as cancer cells or specific organs.
  • Enhanced cellular uptake: Peptide-functionalized nanoparticles can improve cellular uptake due to the affinity of certain peptides for cell surface receptors. This is especially useful for drug delivery applications where efficient absorption is critical.
  • Biocompatibility: Peptides are generally biocompatible to minimize immune responses, making them suitable for use in biological systems. This property is critical for applications such as drug delivery and imaging.
  • Versatility: Peptide-nanoparticle conjugates can carry multiple functions by attaching various peptides or biomolecules to the nanoparticle surface. This enables the conjugate to perform multiple tasks simultaneously, such as targeting, imaging and therapy.
  • Stability and solubility: Nanoparticles can enhance the stability and solubility of peptides, which may themselves be unstable or insoluble. Binding peptides to nanoparticles prevents their degradation and improves their overall performance.
  • Responsive behavior: Peptide-nanoparticle conjugates can be designed to respond to specific environmental cues, such as pH, temperature, or enzyme activity. This responsiveness can be used to trigger drug release or other controlled actions.
  • Custom Design: The design of peptide sequences and nanoparticle properties can be fine-tuned to achieve desired functions and interactions, allowing for a high degree of customization and optimization.

Our Featured Services

  • Side Chain Peptide Nanoparticle Customization Service

One of the methods to prepare side chain peptide functionalized nanoparticles is to employ various free radical polymerization techniques. In this approach, monomers groups susceptible to chemoselective reactions are polymerized in their protected or unprotected form and then reacted with an appropriate functional peptide. CD Bioparticles is able to provide comprehensive custom synthesis services for side chain functional nanoparticles.

  • Endopeptide Nanoparticle Customization Service

CD Bioparticles can use a variety of controlled or living polymerization techniques, combined with appropriate functional initiators, to prepare alopeptide nanoparticles. These initiators are designed to be inert to polymerization in their native or protected form and to be activated after polymerization is complete. In addition, the process can also be terminated by a functional terminator, which endows the nanoparticles with specific functional groups.

  • Peptide-Nanoparticle Complex Self-Assembly Customization Service

CD Bioparticles provides advanced synthetic strategies by using peptide molecules to self-assemble peptide-copolymers to obtain unique peptide-copolymer structures, especially in the fields of catalysis and drug delivery.

  • Surface-Deposited Peptide-Nanoparticle Complex Custom Service

Surface-deposited peptide-nanoparticle complexes are able to self-assemble into well-defined nanostructures, resulting in novel nanoparticles and biomolecular materials with unique properties and bioactivities. CD Bioparticles can construct surface structures with attractive bioactive functions by directly conjugating nanoparticles with biomolecules and gradually immobilizing them onto surfaces.

The applications of peptide-nanoparticles conjugates include:

By designing amphiphilic structures into peptide-nanoparticle complexes, they can self-assemble into functional biomolecular nanostructures, such as spherical micelles, cylindrical micelles, and vesicles, when dissolved in selective solvents.

Protein-nanoparticle conjugates can be assembled with synthetic block copolymers to generate composites with hierarchical structural complexity and exhibit specific chemical functions within specific microdomains of block copolymer films.

Peptides such as polyaspartic acid, polyglutamic acid, and polylysine have been used in the field of small molecule anticancer drugs and gene delivery. In addition, peptide-PEG micelles were also used to prolong drug circulation time and achieve controllable drug release.

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  1. Vila-Gómez P, et al.; Peptide Nanoparticles for Gene Packaging and Intracellular Delivery. Methods Mol Biol. 2021, 2208:33-48.
  2. Zhou Y, et al.; Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy. ACS Nano. 2023, 17(9):8004-8025.
  3. Pan H, et al.; Cytolytic peptide nanoparticles ('NanoBees') for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011, 3(3):318-27.
  4. Jeong WJ, et al.; Peptide-nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms? Nano Converg. 2018, 5(1):38.
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