Aptamer has been developed for the treatment of various diseases because of its good binding affinity and specificity. It can be used not only as a therapeutic agent alone, but also as a carrier for covalent or non-covalent binding to drugs for targeted drug delivery.
CD Bioparticles provides synthesis and modification services for targeted drug delivery aptamers, enhancing the binding affinity of aptamers to targets, improving stability and avoiding nuclease degradation in vivo. We have extensive experience in aptamer synthesis and modification, and can provide aptamer synthesis and modification based on your different experimental needs.
Rapid advances in aptamer development and nanotechnology have made aptamers an attractive tool for biomedical applications. They can be easily chemically modified and several modifications can be easily achieved without compromising aptamer-target interactions.
Aptamer modifications can enhance binding affinity to the target, improve stability, avoid in vivo nuclease degradation, and enhance their in vivo stability and pharmacokinetics in the biological environment. Many new polymerases can be used to generate a more stable aptamer library that prevents nuclease hydrolysis. In addition, stability can be enhanced by introducing non-natural nucleotides into the library, a process that can be achieved by altering the sugar loop, including 2′-fluoro-ribose, 2′-amino-ribose, 2′-O-methyl-ribose and LNA (covalently linked 2′- and 4′-ribose positions).
Fig.1 SELEX with modified nucleotide bases, sugar rings, or phosphates. (a) Modifications (R) are employed for the selection of SOMAmers including benzyl, naphthyl, and indole (right). (b) Modifications (including F, NH2, OMe, LNA) on sugar rings can be incorporated into aptamers during selection. (c) Increased stability can also be garnered through phosphorothioate (PS) and phosphorodiothioate (PS2) linkages. (Ni S, et al., 2021)
CD Bioparticles provides synthesis and modification services for different types of aptamers, enhancing the stability, structural diversity and powerful target binding ability of aptamers in biofluids. We currently offer synthesis and modification services for the following aptamers, but our services are not limited to these:
CD Bioparticles provides synthesis and modification services of targeted drug delivery aptamers, enhancing the binding affinity of aptamers to targets, and can provide aptamer synthesis and modification based on your different experimental needs. If you are interested in our services, please do not hesitate to contact us for more detailed information.