A Porous Hydrogen-Bonded Organic Framework Material for the Sustained Release of Ibuprofen

Zhu, YL; Zhang, W; Chen, FQ; Shen, PL; Xu, SQ; Xu, H

Abstract

Design and synthesis of drug delivery carrier for targeted and controlled drug release is very vital but challenging. In this work, based on organic ligand molecule 2,4,6-tris(4-carboxyphenyl)aniline (BTB-NH2), a porous hydrogen-bonded organic framework material HOF-BTB-NH2 was designed and synthesized for targeted drug delivery. The anti-inflammatory drug Ibuprofen (IBU) was effectively loaded in the HOF-BTB-NH2, and it took 6 hours to release IBU completely in PBS buffer solution. This work demonstrates that the porous HOF materials are promising candidates for targeted drug delivery applications.

Keywords: porous materials; hydrogen-bonded organic framework; organic ligand; drug sustained release; ibuprofen

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Hydrogen-bonded Organic Framework (HOF) Materials

Hydrogen-bonded organic framework (HOF) is a crystalline material with a microporous structure, usually built from organic molecules, in which hydrogen bonds play a key role. The microporous structures of these materials can be used to adsorb, separate and store gases and small molecules, including drug molecules. Therefore, HOF materials have potential application value in drug delivery.

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