MOF as nanoscale drug delivery devices: Synthesis and recent progress in biomedical applications

Moharramnejad, M; Ehsani, A; Shahi, M; Gharanli, S; Saremi, H; Malekshah, RE; Basmenj, ZS; Salmani, S; Mohammadi, M

Abstract

Metal-organic frameworks (MOFs) have received a lot of attention for application as nanoscale drug delivery devices due to their unique properties in high storage capacities, multiple functionalities, and excellent bio-compatibilities. and abundant functionalities. Several strategies can be used to synthesise including traditional reactions (solvothermal or non-solvothermal methods), microwaves, electrochemistry, sonochemistry, mecha-nochemistry. MOFs are composed of metal ions/metal clusters linked by multitopic organic ligands containing sulfonate, carboxylate, and phosphonate groups. The various methods for modifying the surfaces of MOFs are described with covalent bonds and covalent bonds. The application of functional groups, MOFs are developed to produce high porous materials through covalent and non-covalent bonds. MOFs are used to encapsulate various drugs and other macromolecules including nucleic acids, DNA, siRNA and properties.

Keywords: Metal-organic frameworks (MOFs); Drug delivery; Covalent bonds; Ligand; Metals

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Metal-organic Frameworks (MOFs) Materials

Metal-Organic Frameworks (MOFs) have emerged as a transformative platform for drug delivery, showcasing unparalleled versatility and controllable release properties. MOFs are crystalline structures composed of metal ions interconnected by organic ligands, forming a porous framework. This unique architecture allows for the precise encapsulation of therapeutic agents within the pores, safeguarding drugs from premature degradation. The tunable nature of MOFs enables the customization of pore size, surface area, and functionality, tailoring them for specific drug-loading and release requirements. Additionally, the biocompatibility of MOFs enhances their potential for in vivo applications. The controlled release of drugs from MOFs can be triggered by stimuli such as pH, temperature, or specific ions, ensuring targeted and sustained therapeutic effects.

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