A Comparative Study of Two Bone Graft Substitutes-InterOss(R) Collagen and OCS-B Collagen(R)

Jain, G; Blaauw, D; Chang, S

Abstract

Bone is a complex hierarchical tissue composed of organic and inorganic materials that provide structure, support, and protection to organs. However, there are some critical size defects that are unable to regenerate on their own and therefore require clinical repair. Bone graft substitutes allow repair by providing a temporary resorbable device. Among the common filler materials that aid in regeneration is hydroxyapatite particles of either animal or human origin which is used to fill or reconstruct periodontal and bony defects in the mouth. However, particulate graft substitutes suffer from localized migration away from the implantation site, necessitating the use of a barrier membrane. In this study, we designed InterOss Collagen, combining bovine hydroxyapatite granules with porcine-skin derived collagen to form a bone filler composite. Physiochemical properties of InterOss Collagen and a commercially available product, OsteoConductive Substitute-Bovine (OCS-B) Collagen, referred to as OCS-B Collagen, were examined. We found two bone graft substitutes to be mostly similar, though InterOss Collagen showed comparatively higher surface area and porosity. We conducted an in vivo study in rabbits to evaluate local tissue responses, percent material resorption and bone formation and showed that the two materials exhibited similar degradation profiles, inflammatory and healing responses following implantation. Based on these results, InterOss Collagen is a promising dental bone grafting material for periodontal and maxillofacial surgeries.

Keywords: bone; hydroxyapatite; collagen; bone graft substitute; bone fillers

Related products/services

Tissue Engineering Scaffold

Collagen-based engineered bone scaffold is an advanced biomaterial for bone tissue repair and regeneration. With collagen as the main component, this scaffold mimics the structure and characteristics of natural bone tissue, providing an ideal growth environment for bone cells. It is biocompatible, and the stent has no foreign body reaction with tissues in the body, reducing the risk of rejection. The biodegradability of the scaffold allows it to be gradually absorbed by the body, promoting the formation of new bone tissue. Collagen-based engineered bone scaffolds promote the attachment, proliferation and differentiation of bone cells through bioactive groups on the surface, and accelerate the regeneration process of bone tissue. The structural adjustability allows it to adapt to the bone defects and morphological needs of different patients. This advanced bone scaffold shows excellent clinical application prospects in fracture healing, implant support, and bone defect repair, and provides important support for the successful implementation of bone tissue engineering.