Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration

Geahchan, S; Baharlouei, P; Rahman, A

Abstract

Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water soluble, metabolically compatible, and highly accessible. Upon review of the literature, it is evident that marine collagen is a versatile compound capable of healing skin injuries of varying severity, as well as delaying the natural human aging process. From in vitro to in vivo experiments, collagen has demonstrated its ability to invoke keratinocyte and fibroblast migration as well as vascularization of the skin. Additionally, marine collagen and derivatives have proven beneficial and useful for both osteoporosis and osteoarthritis prevention and treatment. Other bone-related diseases may also be targeted by collagen, as it is capable of increasing bone mineral density, mineral deposition, and importantly, osteoblast maturation and proliferation. In this review, we demonstrate the advantages of marine collagen over land animal sources and the biomedical applications of marine collagen related to bone and skin damage. Finally, some limitations of marine collagen are briefly discussed.

Keywords: marine collagen; wound healing; bone regeneration; collagen peptides; antiaging; osteoporosis; osteoarthritis; fish collagen; marine sponge

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Collagens

Marine collagen, derived from fish skin, scales, and bones, has gained significant attention in recent years for its remarkable therapeutic properties in wound healing, skin anti-aging, and bone regeneration. Rich in amino acids like glycine, proline, and hydroxyproline, marine collagen plays a crucial role in supporting the structure and integrity of skin, bones, and connective tissues. When applied topically or consumed orally, it promotes collagen synthesis, enhancing skin elasticity, reducing wrinkles, and improving overall skin tone and texture. Moreover, marine collagen possesses impressive wound healing capabilities, facilitating the repair of damaged tissues by stimulating the production of new collagen fibers and accelerating the formation of granulation tissue. Its bioactive components also aid in bone regeneration by promoting osteoblast activity and mineralization, thus strengthening bones and preventing conditions like osteoporosis. Additionally, marine collagen exhibits excellent biocompatibility and low immunogenicity, making it a safe and effective option for various medical and cosmetic applications. With its multifaceted benefits, marine collagen stands as a promising natural resource for promoting health, vitality, and longevity, offering a holistic approach to skincare, wound management, and bone health. As research continues to uncover its therapeutic potential, marine collagen is poised to revolutionize the fields of regenerative medicine and anti-aging skincare, providing individuals with sustainable solutions for enhancing their well-being and quality of life.