Ultrathin Covalent Organic Framework Nanosheets/Ti3C2Tx-Based Photoelectrochemical Biosensor for Efficient Detection of Prostate-Specific Antigen

Li, NJ; Wang, CY; Chen, LJ; Ye, C; Peng, YW

Abstract

Designable and ultrathin covalent organic framework nanosheets (CONs) with good photoelectric activity are promising candidates for the construction of photoelectrochemical (PEC) biosensors for the detection of low-abundance biological substrates. However, achieving highly sensitive PEC properties by using emerging covalent organic framework nanosheets (CONs) remains a great challenge due to the polymeric nature and poor photoelectric activity of CONs. Herein, we report for the first time the preparation of novel composites and their PEC sensing properties by electrostatic self-assembly of ultrathin CONs (called TTPA-CONs) with Ti3C2Tx. The prepared TTPA-CONs/Ti3C2Tx composites can be used as photocathodes for PEC detection of prostate-specific antigen (PSA) with high sensitivity, low detection limit, and good stability. This work not only expands the application of CONs but also opens new avenues for the development of efficient PEC sensing platforms.

Keywords: covalent organic framework nanosheets; Ti3C2Tx; composites; photoelectrochemical biosensor; prostate-specific antigen

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Covalent Organic Framework (COF) Materials

Covalent organic framework (COF) is a material with a highly ordered structure that has been widely used in the field of photoelectrochemical biosensors. COFs, through their unique pore structure and surface functionalization, provide an ideal environment that facilitates the embedding and transport of biomolecules. In biosensors, COF is designed to improve the sensitivity and selectivity of the sensor and achieve efficient detection of biomolecules through photoelectrochemical reactions. These frameworks possess superior stability and tunability, enabling accurate and rapid detection in complex biological samples. The application of COF provides new possibilities for the development of photoelectrochemical biosensors and is expected to have an important impact in fields such as medicine and environmental monitoring.