Targeted Lipid-PEGs

Polyethylene glycol (PEG) -lipid conjugates are PEG derivatives containing lipid molecules, such as DMG or DSPE, that have been used for bioconjugation and lipid nanoparticle (LNP) drug delivery to improve the cycle time of liposomal encapsulated drugs. Lipid molecules are characterized by low toxicity and ease of preparation. It can be used as a carrier of both water-soluble and lipid-soluble drugs. Therefore, PEG liposomes can be used to improve drug stability, achieve multi-pathway drug delivery, and achieve targeted drug delivery.

CD Bioparticles’ services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Lipids delivery models are unstable of thermodynamics in vitro or in vivo studies
• Chemotherapy can have severe toxic side effects on normal cells and tissues
• The concentration of the drug at the tumor site is low
• The slow release of drugs causes the body's cells to develop resistance
• The lipid metabolism pathway of various regulatory factors is not clear
• Some cancers are difficult to treat directly with chemicals
• Tedious liposome formulation, purifications, and production

Key benefits:

• Prolong the time the drug circulates through the body
• Increase the stability and solubility of the drugs contained
• Reduce the toxicity and side effects of drugs and improve their efficacy
• Simple operation, selective, low cost
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• To deliver antitumor drugs
• Develop techniques for the determination of biological matter and biological activity
• Rapid screening of enzyme inhibitors
• Used to synthesize and characterize new polymerizable lipids