Temperature Response


Temperature response copolymers undergo reversible changes in properties, such as solubility or structure, in response to changes in temperature. Because of their ability to release drugs in a controlled and temperature-dependent manner, these copolymers have received great attention in drug delivery systems. These temperature response copolymers provide versatility for designing drug delivery systems with adjustable release rates and enhanced drug stability. By taking advantage of the temperature responsiveness of these copolymers, drug delivery systems can be tailored for specific applications, such as local drug delivery for cancer treatment or temperature-triggered drug release for targeted therapies.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Drug degradation or premature release
  • The toxicity of therapeutic drugs can cause damage to normal cells
  • The concentration of the drug at the tumor site is low
  • Tedious copolymers formulation, purifications, and production

Key benefits:

  • Thermo responsive behavior: exhibit a sharp phase transition at a specific temperature known as the lower critical solution temperature (LCST); this property enables the encapsulated drugs to be released in response to temperature changes, providing a trigger for controlled drug release.
  • Stimulus-triggered release: the ability to undergo sol-gel transition in response to temperature changes. When the copolymer is below the LCST, it remains in a sol state, ensuring easy drug encapsulation. However, once the temperature rises above the LCST, the copolymer undergoes a gelation process, resulting in the sustained release of the encapsulated drug.
  • Targeted drug delivery: be designed to respond to specific temperature ranges found in various body tissues; this allows for site-specific treatment and reduces systemic side effects.
  • Good stability and biocompatibility
  • Versatile encapsulation methods: used to encapsulate a wide range of drug molecules, including small molecules, proteins, peptides, and nucleic acids.
  • Suitable for in vitro and in vivo experiments
  • Ready-to-use

Application candidates:

  • Tissue Engineering: to be utilized in tissue engineering to create scaffolds that mimic the extracellular matrix. These copolymers can undergo gelation or sol-gel phase transitions at specific temperatures, making them suitable for cell encapsulation and promoting cellular growth and tissue regeneration.
  • To be used to develop responsive coatings on surfaces. This coating can be used in anti-fouling, anti-bacterial and controlled release systems.
  • To be used to develop sensors, actuators and smart materials that respond to temperature changes.
  • Being explored for various biomedical devices such as injectable hydrogels, wound dressings, and drug-eluting stents.
  • Used in microfluidic devices that require precise control of fluid flow and manipulation.

PHEMA

Catalog: PHRC511

PEG MW: 20000 Da

PHPMA

Catalog: PHRC510

PEG MW: 30000 Da - 50000Da

PNIPAM

Catalog: PHRC509

PEG MW: 60000 Da -10000 Da

Poly(HEMA)

Catalog: CDP23-079-L

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