Metal-organic Frameworks (MOFs) Linkers

Metal-organic framework (MOF) materials use inorganic metal ions as structural centers and basic organic ligands to undergo coordination reactions under certain catalysis and temperature conditions, and generate coordination bonds through coordination reactions. Molecules are connected to each other to form a new material with porous network characteristics. Briefly, metal-organic frameworks are coordination networks with organic ligands that contain potential voids. Coordinated networks are coordinated compounds that extend through one-dimensionally repeating coordination entities but have cross-links between two or more single chain, loop, or helical links, or through two or three repeating coordination entities. These coordinated compounds with cross-links are known as metal organic framework linkers.

Figure 1. The self-assemble of the organic linker and metal ions for the synthesis of MOFs.(Hani N. A., et al.; 2020)

Metal-organic frameworks (MOFs) have been widely used in biomedical research, especially as platforms for cancer treatment. The main reasons are as follows: First, MOFs have the characteristics of large specific surface area and adjustable pore size. They can be used as an excellent and efficient drug nanocarrier, significantly improving the bioavailability and tumor targeting of related drugs. Second, almost any metal ion can form MOFs with suitable ligands. Therefore, MOFs of specific metal ions can also be prepared, which can not only greatly improve the efficiency of cancer tumor treatment, but also confer other functions in treatment.

To further advance research on MOFs in drug delivery, CD Bioparticles provides high-quality Metal-organic Frameworks (MOFs) linkers products to help solve the following challenges.

The challenges you might meet:

• Control pore structure
• Functionalized MOF surface
• Introducing active sites
• adjust electronic structure
• Improve synthesis efficiency
• Achieve versatility

MOFs linkers products key features:

• Multi-Carboxylic MOFs Linkers
• 2d-Carboxylic MOFs Linkers
• 3d-Carboxylic MOFs Linkers
• 4d-Carboxylic MOFs Linkers
• Multi-Nitrogen MOFs Linkers
• 2d-Nitrogen MOFs Linkers
• 3d-Nitrogen MOFs Linkers
• Multi-Hybrid MOFs Linkers
• 2d-Hybrid MOFs Linkers
• 3d-Hybrid MOFs Linkers
• A2B2-Porphyrins
• A3B1-Porphyrins
• A4-Porphyrins
• Bipyridine Blocks
• Halide Substituted Aromatics
• Metalloporphyrins
• Tetraphenylethylene
• Triphenylbenzene
• Customizable MOFs Linkers
• Isophthalate
• Other MOFs Linkers
• Other Organic-Linker Blocks

MOFs linkers products key benefits:

• MOF linkers can control the pore structure of MOF by selecting specific organic ligands and metal centers.
• MOF linkers can be surface functionalized by introducing different functional groups or ligands to impart specific properties to the MOF. This includes enhancing the chemical stability of MOFs, improving catalytic activity, realizing drug delivery functions, etc.
• MOF linkers can be used to introduce catalytically active metal centers or ligands, making MOFs effective catalysts.
• MOF connectors can adjust the electronic structure of the metal center in MOF and affect its optical and electronic properties.
• The use of MOF linkers can promote the synthesis process of MOF and improve the yield and synthesis efficiency. The introduction of linkers can help form a stable structure and accelerate the formation process of MOF.
• The design and introduction of MOF connectors can realize the versatility of MOF, making it have a wide range of applications in different fields.

MOFs linkers products application candidates:

• Participating in the construction of MOFs that can be used as carriers for drug delivery systems can achieve efficient loading and controlled release of drugs by regulating their pore structure and surface functionalization.
• Construction of MOFs with potential applications in the field of medical imaging can be used as carriers of imaging contrast agents.
• Participate in the construction of MOFs for the preparation of biosensors.
• Participate in the construction of MOFs for tissue engineering and repair.  Its tunable pore structure and biocompatibility make it a potential candidate material for cell culture scaffolds, helping to promote tissue regeneration and repair.
• Participating in the construction of MOFs as carriers for gene delivery can achieve gene protection and targeted delivery, and is expected to be used in the fields of gene therapy and gene editing.