PEG-derivatives for Drug Development

Today we offer you:

Fully certified high-quality PEG derivatives. They are an excellent choice for your PEG derivative supply if you seek to translate your R&D efforts into faster commercialization:

• High-purity PEG derivatives with a wide variety of functional groups from R&D to commercial scale, in both non-GMP and GMP grades.
• Large format, high purity PEG raw materials for chemical, biological, medical and commercial applications.
• Custom PEG synthesis services to meet the unique needs of clients' projects.
• Whenever you encounter any technical problems, we are always happy to provide you with scientific advice!

Table of Contents

• PEGylation
• LNPs Delivery System Excipients
• PEG Linkers for ADC Drugs
• PROTAC Linkers
• PEG Hydrogels for Medical Devices
• Dye Labeling
• 3D Printing
• PEG Raw Materials
• Featured Monodispersed Linear PEGs
• Featured Heterobifunctional Linear PEGs

PEGylation

PEGylation is the covalent addition of PEG to another molecule, which is mainly coupled to peptides, proteins and antibody fragments in the biomedical field.

Significant pharmacological advantages of PEGylation peptides, proteins and antibody fragments include:

1) Improvement of drug solubility

2) Reduction of potential drug toxicity

3) Reduction of dosage frequency

4) Enhancement of drug stability, especially protection against protein drug degradation

PEGylation Reagents

Product Name	Structural Formula	PEG MW	CAS NO.
mPEG-SC		550, 750, 1k, 2K, 3.4K, 4K, 5K, 10K, 12K, 20K, 30K, 40K Da	-
mPEG-Mal		1k, 2K, 3.4K, 5K, 10K, 20K, 30K, 40K Da	-
t-Boc-N-amido-PEG3-CH2CO2H		-	462100-06-7
Fmoc-NH-PEG4-COOH		-	557756-85-1
mPEG-ALD		350, 550, 750, 1k, 2K, 3.4K, 5K, 10K, 12K, 20K, 30K, 40K Da	-
mPEG-SPA		350, 550, 750, 1k, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K, 30K, 40K Da	-
Amino-PEG2-t-butyl ester		-	756525-95-8
t-Boc-N-amide-PEG2-CH2CO2H		-	108466-89-3

LNPs Delivery System Excipients

Lipid nanoparticles (LNPs) are commonly used drug delivery systems in the field of nucleic acid drugs. The LNP technology is mainly developed for vaccine development.

Among them, PEG is commonly used to improve the stability of LNPs.

Product Name	Structural Formula	PEG MW	CAS NO.
mPEG-DTA		2K, 3.4K, 5K, 10K Da	1849616-42-7
mPEG-DMG		550, 1K, 2K, 3.4K, 5K, 10K Da	160743-62-4
mPEG-CH2CH2CH2-NH2		2K, 3.4K, 5K, 10K Da	-
DSPE-PEG-Mannose		1K, 2K, 3.4K, 5K, 10K, 20K Da	-
mPEG-DPPE		2K, 5K Da	205494-72-0
mPEG-DSPE		350, 550, 750, 1K, 2K, 3.4K, 4K, 5K, 10K, 20K, 30K, 40K Da	147867-65-0
mPEG-AA		350, 550, 750, 1K, 2K, 3.4K, 4K, 5K, 10K, 20K, 30K, 40K Da	-
mPEG-OH		350, 550, 750, 1K, 2K, 3.4K, 4K, 5K, 10K, 20K, 30K, 40K Da	9004-74-4
DSPE-PEG-NH2		200, 400, 500, 600, 800, 1K, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K Da	474922-26-4
DOPE-PEG-NH2		2K, 3.4K, 5K, 10K Da	-
DOPE-PEG-FA		2K Da	-
CLS-PEG-OH		1K, 2K, 5K Da	-
Palmitic acid-PEG-NH2		2K, 5K Da	-

PEG Linkers for ADC Drugs

Antibody-drug conjugates (ADCs) are a class of targeted therapeutics for the treatment of cancer, consisting of monoclonal antibodies (Antibody) targeting tumor-specific or tumor-associated antigens coupled with different numbers of small molecule toxins (Payloads) via linkers. The chemistry of the linker affects various properties of ADCs, including toxicity, specificity, stability and potency.

PEG linkers are particularly attractive as linkers for antibody-drug couplers (ADCs):

1) Increase drug solubility and stability

2) Reduce toxicity

3) Reduce immunogenicity, improve pharmacokinetics and increase circulation time

Product Name	Structural Formula	Molecular weight	Purity
COOH-PEG4-NH2.HCl		301.81	≥95%
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid		554.6	≥95%
mPEG25-SPA		1301	≥95%
Mal-PEG12-NHS		794	≥95%
Mal-NH-PEG8-COOH		592.6	≥95%
Alkyne-PEG4-NH2		231.3	≥95%
mPEG-SCM		-	≥95%
N3-PEG3-SPA		344.3	≥95%
Mal-PEG3-COOH		301.3	≥95%
N-(Hydroxy-peg3)-n-boc-peg4-t-butyl ester		597.74	≥95%
NH2-PEG12-OH		545.667	≥95%
mPEG36-NH2		1616.95	≥95%

PROTAC Linkers

PROTAC is a bifunctional molecule that efficiently and specifically catalyzes the degradation of disease-causing proteins. It consists of three parts: a target protein binding ligand at one end, an E3 ubiquitin ligand at the other end, and a linker chain in the middle.

PEG linkers are the most common motifs in the PROTAC linker structure.

Product Name	Structural Formula	Molecular weight	Purity
Tos-PEG3-O-C1-CH3COO		376.42	≥95%
Boc-NH-PEG2-Tos		403.49	≥95%
Tos-PEG2-NH2		259.32	≥95%
Thalidomide-O-PEG5-Tosyl		578.61	≥95%
Dox-Ph-PEG1-Cl		228.67	≥95%
NH2-Ph-C4-acid-NH2-Me		222.28	≥95%
Boc-NH-PEG2-C2-amido-C4-acid		376.45	≥95%
Boc-C1-PEG2-C4-Cl		294.81	≥95%
Thalidomide-O-amido-PEG3-NH2		506.509	≥95%
Tos-PEG4-Tos		502.6	≥95%
Boc-NH-PEG3-OH		249.3	≥95%
Pomalidomide-PEG4-Ph-NH2		540.57	≥95%

PEG Hydrogels for Medical Devices

Multi-arm PEG derivatives are mostly employed in the formation of hydrogels. PEG hydrogels can be used to prepare drug slow-release systems, tissue engineering, cell culture, wound sealing, wound healing and so on. In drug slow-release systems, PEG-PLA hydrogels can be used as carriers to control the release rate of drugs. In tissue engineering, PEG-DA hydrogel can be used as the scaffold material for cell culture and tissue repair.

Product Name	Structural Formula	PEG MW	Purity
8-Arm-PEG-SS		5K, 10K, 20K, 40K Da	≥95%
8-Arm-PEG-SG		5K, 10K, 20K, 40K Da	≥95%
4-Arm-PEG-SS		2K, 5K, 10K, 20K, 40K Da	≥95%
4-Arm-PEG-SG		2K, 5K, 10K, 20K, 40K Da	≥95%
8-Arm-PEG-SH		10K, 20K, 40K Da	≥95%

Dye Labeling

PEGylated fluorescent dyes enhance specific tumor labeling. The PEG chains alter tissue biodistribution, allowing brighter liver metastases labeling and decreased accumulation in normal organs, particularly the liver.

3D Printing

3D printing has become a promising frontier in the field of complex tissue engineering due to its porosity, biodegradability and good biocompatibility. PEG derivatives are particularly attractive in three-dimensional printing due to their good biocompatibility under both in vitro and in vivo conditions.

Product Name	Structural Formula	PEG MW
AC-PEG-RGD		2K, 3.4K, 5K Da
8-Arm-PEG-Acrylate		5K, 10K, 20K, 40K Da
ACRL-PEG-ACRL		400, 600, 800, 1k, 2K, 3.4K, 5K, 10K, 20K Da

PEG Raw Materials

CD Bioparticles provides high purity PEG raw materials (linear and multi-arm PEG) for chemical, biological, medical and industrial applications in batch sizes of 5kg, 15kg, 20kg and 100kg. These PEG raw materials are suitable for further derivatization into PEG derivatives.

Product Name	Structural Formula	PEG MW
4-Arm-PEG-OH		5K, 10K, 20K, 40K Da
mPEG-OH		1K, 2K, 3.5K, 5K, 10K, 20K, 40K Da
NH2-PEG-NH2		1K, 2K, 3.4K, 5K, 10K, 20K, 40K Da
Trt-PEG-OH		1K, 1.2K, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K Da
HO-PEG-OH		200, 400, 500, 800, 1K, 1.2K, 2K, 3.4K, 5K, 10K, 20K, 40K Da

Featured Monodispersed Linear PEGs

Product Name	Structural Formula	Molecular weight	Purity
(2-pyridyldithio)-PEG2-t-butyl ester		359.5	≥95%
2-((Azide-PEG8-carbamoyl)methoxy)acetic acid		554.6	≥95%
N3-PEG3-OH		175.186	≥95%
SH-PEG3-SH		226.4	≥95%
Mal-NH-PEG4-NHS		513.5	≥95%
NH2-PEG3-OH		149.18	≥95%
Boc-NH-PEG3-Tos		447.54	≥95%
Trityl-PEG7-N3		637.8	≥95%
OH-PEG4-Tos		348.412	≥95%
OH-PEG9-OH		414.488	≥95%
N3-PEG3-COOH		247.3	≥95%
Fmoc-NH-PEG8-CH2COOH		649.7	≥95%
NH2-PEG5-CH2CH2COOtBu		365.5	≥95%
CLS-PEG4-NH-Mal		856.14	≥95%
N3-PEG3-SPA		344.3	≥95%

Featured Heterobifunctional Linear PEGs

Product Name	Structural Formula	PEG MW	Purity
SH-PEG-Biotin		200, 400, 500, 600, 800, 1K, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K Da	≥95%
SH-PEG-NH2		200, 400, 500, 600, 800, 1K, 2K, 3.4K, 5K, 6K, 8K, 10K, 20K Da	≥95%
Mal-PEG-SCM		1K, 2K, 3.4K, 5K, 7.5K, 10K, 20K Da	≥95%
HO-PEG-Propylamine-Boc		3.4K Da	≥95%
Br-CH2CO-NH-PEG-OH		1K, 2K, 5K Da	≥95%
Boc-NH-PEG-SH		2K, 3K, 3.4K, 5K, 10K Da	≥95%
PLGA(15K)-PEG-Mal		2K, 3.5K, 5K, 10K Da	≥95%
Phosphoric acid-PEG-COOH		2K Da	≥95%
I-PEG-COOH		2K, 5K Da	≥95%
N3-PEG-Br		2K, 5K, 10K, 20K Da	≥95%
Bn2-PEG-OH		1K, 1.5K, 2k, 3.4K, 5K, 10K, 20K Da	≥95%
DF-PEG-NH2		2K, 3.4K, 5K Da	≥95%
DBCO-PEG-AC		1K, 2K, 5K, 10K Da	≥95%
HZ-PEG-N3		2K, 3.4K, 5K, 10K Da	≥95%
ACA-PEG-SVA		3.4K Da	≥95%