Polyethylene Glycols (PEGs) for Pharmaceutical Application

Today we offer you:

A fully certified high purity polydisperse and monodisperse PEG derivatives. These PEG derivatives have been widely used in bioconjugation, antibody-drug conjugates (ADCs) therapeutic, drug delivery, medical materials, diagnostics field, etc.

• High purity pharmaceutical PEG derivatives with an extensive variety of functional groups
• Providing custom PEG derivatives in milligram to hundreds of kilograms or greater with GMP standard manufacturing capability
• Custom analytical test methods for customized PEG derivatives in order to adjust our testing to best fit your needs
• Instant expert scientific support

Polydisperse PEG Derivatives

PEG can be divided into monodisperse PEG and polydisperse PEG. Monodispersed PEG are homogeneous polymers and have a single molecular weight, while Polydisperse PEG are heterogeneous and contain polymer chains of unequal length. Thus the polydisperse PEG molecular weight is not a single value—the polymer exists as a distribution of chain lengths and molecular weights.

Polydisperse PEGs are very useful in the development of PEGylated protein drugs, helping to increase drug half-life and lower clearance rates. For example, poly PEG in PEGylated lipid nanoparticles has been used in COVID-19 mRNA vaccines and gained international attention. PEG lipids have been widely applied to improve the circulation time of liposome-encapsulated (LNP) drugs and reduce nonspecific uptake.

Features

• Diverse product structure
• Rich in substitution
• High substitution rate of end group

Polydisperse PEG Derivatives

Product Name	Molecular Weight	CAS No.	Structural Formula
mPEG-NH2	2KDa, 5KDa, 10KDa, 20KDa	80506-64-5
mPEG-pALD	2KDa, 5KDa, 10KDa, 20KDa	125061-88-3
AA-PEG-AA	2KDa, 5KDa, 10KDa, 20KDa	26570-48-9
HOOC-PEG-OH	5KDa, 10KDa, 20KDa, 40KDa	39927-08-7
2-arm PEG-CHO	2KDa, 5KDa, 10KDa, 20KDa, 40KDa	--
4-arm PEG-MAL	2KDa, 5KDa, 10KDa, 20KDa, 40KDa	357277-62-4
4-arm PEG-SC	2KDa, 5KDa, 10KDa, 20KDa, 40KDa	--
8-arm PEG-NH2	5KDa, 10KDa, 20KDa, 40KDa	--

Monodisperse PEG Derivatives

Monodisperse PEG products are typically organic compounds with molecular weights less than 1000. The monodisperse of PEGs may play a role in the development of safe and effective PEGylated small-molecule drugs, which can confer flexibility, anticoagulation, anti-macrophage phagocytosis, etc. to the modified biomolecules. Currently, monodisperse PEGs are used in many fields, including nanotechnology, drug release, pharmaceutical industry, and biomedical research.

In drug delivery, PEG can be used as a linker for antibody-drug conjugates (ADCs) or as a surface coating on nanoparticles to improve systemic drug delivery. Previous studies have found that the incorporation of monodisperse PEG into small molecule drugs can increase the solubility and molecular weight of the drug, thereby prolonging the half-life of the drug in vivo, while reducing the steric hindrance and binding effects generated when the protein is modified by high- molecular PEG.

Product Name	Structural Formula	CAS No.	Structural Formula
HO-PEG1-CH2CH2COOtBu	C9H18O4	671802-00-9
H2N-PEG2-CH2CH2COOtBu	C11H23NO4	756525-95-8
N3-PEG3-OH2CH2COONHS Ester	CH20N4O7	1245718-89-1
N3-PEG4-OH	C8H17N3O4	86770-67-4
N3-PEG6-CH2COOH	C14H27O8N3	880129-82-8
N3-PEG10-CH2CH2NH2	C22H46O10N4	912849-73-1

Monodisperse PEG Derivatives

Product Name	Structural Formula	CAS No.	Structural Formula
Fmoc-NH-PEG5-CH2CH2	C28H37NO9	882847-32-7
Boc-NH-PEG3-CH2CH2COOH	C14H27NO7	1347750-75-7
N3-PEG6-CH2CO2-NHS	C18H30N4O14	--