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Nanomaterials Nanocellulose
Nanocellulose Introduction With the continuous progress of society and human civilization, non-renewable resources such as coal and oil are constantly being consumed, the pressure on the earth’s environment is also increasing, and sustainable development has also risen to the national strategic level. The use of renewable resources, especially green bioenergy, will be an important direction for future research and development applications. Cellulose is abundant in nature. Cellulose is one of the more basic components of plant tissues such as trees that are very common in our lives. In addition to the large reserves in plant tissues, cellulose can also be continuously produced by animals and microorganisms. It is a typical…
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AI Ignites Pharma: A Dynamic New Era of Personalized Medicine Is Unleashed!
AI Development Within the Pharmaceutical Industry AI implementation in the pharmaceutical sector has evolved from fundamental beginnings to advanced technological applications. In the 1980s and 1990s basic computational models were the extent of AI applications in drug research which served molecular modeling and chemical structure prediction. Machine learning algorithms started assisting drug research and development in the early 21st century by analyzing complex data sets and optimizing drug formulations while predicting molecular interactions. The pharmaceutical industry has widely applied AI technology to speed up drug research and development because big data development alongside deep learning technology emerged with numerous biological and chemical data sets. Application of AI in Drug Development…
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Breaking the Blood-Brain Barrier: Liposome Targeted Delivery Technology Reshaping the Treatment Landscape of Alzheimer’s Disease
Although the relationship between β-amyloid protein deposition and the formation of hyperphosphorylated Tau protein and neurofibrillary tangles and Alzheimer’s disease has been elucidated, current treatments can only alleviate symptoms but cannot cure it. Researchers and clinicians commonly aim to identify effective treatments that target disease root causes. The advanced drug delivery system known as liposomes has demonstrated substantial potential for treating Alzheimer’s Disease in recent scientific developments. These systems allow loading multiple active substances for targeted delivery while enhancing targeting and BBB penetration through surface modification to ensure precise drug delivery to specific brain locations. Through surface modification liposomes can be engineered to selectively attach to Aβ for removal and…
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Research on Platelet Drug Delivery System
The main focus of drug carrier research today is to identify carriers that are both safe and effective for clinical treatment applications. As treatment strategies advance researchers regularly update drug delivery systems. Traditional drug delivery systems consist of liposomes and polymer micelles together with nanoparticles but despite their inclusion in clinical trials current versions still encounter limitations. Liposomes struggle to release hydrophobic drugs from their interior yet they encounter rapid clearance in blood circulation. Polyethylene glycol is applied to nanoparticle surfaces to improve their biocompatibility and stability. When multiple administrations occur polyethylene glycol gets recognized by the mononuclear phagocytic system as a foreign substance which activates the immune system and…
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Anti-Tumor Effect of Targeted Drug Delivery by Engineered Exosomes
Cancers are now the leading cause of death in patients all over the world and their incidence has risen with each passing year. Tumours are currently treated with chemical drugs, with surgery, Chinese medicine and radiotherapy thrown in for good measure. Many anti-tumor drugs will kill normal cells and kill tumour cells in the process producing toxic and side effects. Blood vessels, immune cells, interstitial cells, etc., can interact with drugs to interfere with drug delivery and efficacy – which may make it difficult for drugs to penetrate the tumor or get eliminated. Thus, new treatments are desperately needed to have accurate treatment of tumours. Currently, several new delivery technologies…
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Research of Cell Membrane Nano Drug Delivery System and Its Application in Bionic Nanomedicine
Most of the old drugs are currently limited in their effectiveness because of poor pharmacokinetics, simple clearance by the body and cytotoxicity. Nanoparticle technology in particular, Nano drug delivery system is getting a lot of attention and application in medicine in the recent years. Since it is small (1100nm), targets well, and stays in the circulation long enough, NPs are a good candidate as a drug carrier, enabling an enhanced in vivo targeting capability and less nonspecific adverse effects to some degree. But there are also a lot of problems in the clinical use of NPs. NPs, for instance, once inserted into the body will be assessed and excised by…
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Overview of Tumor Organoids
Malignant tumors have become a major challenge in the field of global public health. How to continuously deepen the understanding of the occurrence and development of malignant tumors and continuously optimize the clinical diagnosis and treatment model of tumors is an important issue that needs to be urgently addressed in oncology research. Both basic and clinical scientific research in oncology requires the selection of appropriate research models. However, the common tumor research models currently have many shortcomings. For example, tumor cell line models are difficult to reproduce the pathophysiological characteristics and internal heterogeneity of parental tumors in vitro, and animal models have problems such as low flux, long cycle, high…
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Exosome Nanocarriers for Tumor Treatment
Cancer is an important cause of death in humans. Current treatments such as radiotherapy and chemotherapy are often accompanied by significant side effects and drug resistance. Nanomedicine has become the preferred solution for improving biocompatibility and biodegradable systems. Nowadays, nanoparticles are not only widely used in treatment, but also show great potential in the field of diagnosis. Exosomes as nanocarriers have the characteristics of high biocompatibility, low immunogenicity and excellent penetration ability, and have broad development prospects in tumor diagnosis and treatment. Exosomes were first discovered in 1986. They are nanoscale (40-150 nm) small extracellular vesicles secreted by various cells. Cell membrane proteins and extracellular components fuse with each other…
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Advantages and Disadvantages of Nucleic Acid Aptamers
Nucleic acid aptamers are single-stranded oligonucleotides with the ability to specifically bind to target molecules. Currently, nucleic acid aptamers are screened from large random nucleic acid libraries using SELEX technology. It can identify different types of target molecules such as proteins, viruses, bacteria, cells, etc. Nucleic acid aptamers not only have the specificity of antibodies, but also have many advantages over antibodies, such as a wider range of target molecules, better thermal stability, smaller molecular weight, chemical synthesis, small batch differences and easy modification. Therefore, nucleic acid aptamers have broad application prospects in biomedicine, diagnostic testing, drug development and other fields, but they also face challenges such as patent restrictions…
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Drug Delivery Research of Cancer Cell Membrane-Coated Nanoparticles
In recent years, malignant tumors have posed a serious threat to human health. Chemotherapy, as the main anti-tumor treatment, is often limited in efficacy due to the lack of targeted drug release, which in turn produces high toxicity to normal tissues. At present, most clinical drug molecules are non-targeted, have low bioavailability, require large doses to reach the effective concentration, and are easily excreted quickly, resulting in non-specific toxic and side effects. Cell membranes coated nanoparticles (CNPs) are widely used in cancer treatment due to their high biocompatibility. CNPs can disguise themselves as autologous cells to evade the recognition and clearance of the immune system, prolong blood circulation time and…
