• Gene Delivery

    The Mechanism of Adverse Immune Reactions of LNP-mRNA

    Many clinical trials of mRNA-based drugs or vaccines have failed to successfully pass Phase I or Phase II. The reasons behind this are various, including low efficacy of candidate drugs and lower-than-expected clinical risk/treatment benefit profiles. Preclinical safety assessments aim to identify well-tolerated and efficacious LNP-mRNA formulations, and when toxicity is observed, in vivo, in vitro and ex vivo experiments aim to understand the underlying mechanisms and, ideally, improve the formulations design under development. The main safety issues of LNP-mRNA preparations in preclinical development can be divided into immunopathogenicity and liver and spleen toxicity (only studies on modified and/or dsRNA-purified mRNA are considered). Understand the different formulations of LNP-mRNA preparations…

  • Delivery Method

    PLGA Nano Drug Carrier

    Poly(lactic-co-glycolic acid) (PLGA) is a functional polymer organic compound randomly polymerized by lactic acid (PLA) and glycolic acid (PGA). It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material available on the market. PLGA has good biocompatibility, biodegradability, mechanical strength, good plasticity, surface modification, and drug encapsulation. It has a wide range of uses in the field of biomedical engineering and has been used in drug sustained-release carriers, artificial catheters and tissue engineering scaffold materials. As a drug carrier, PLGA is soluble in common solvents such as acetone and ethyl acetate. The size, shape…

  • Introduction

    Progress in the Development of Targeted Anti-Tumor Antibody-Drug Conjugates

    Antibody-drug conjugates (ADCs) are conjugated products of monoclonal antibodies (mAbs) and cytotoxic small molecules. In tumor treatment, although monoclonal antibodies have good targeting properties, most of them target extracellular or cell surface antigens, have weak anti-tumor activity, have limited therapeutic effect on solid tumors, and are more likely to develop drug resistance; conventional anti-tumor chemotherapy Although drugs have high anti-tumor cell activity, they lack targeting and often accidentally damage normal cells in the body, causing serious side effects. Antibody-drug conjugates complement each other perfectly, combining the high specificity of antibodies with the high toxicity of cytotoxic drugs to tumors. They can specifically kill tumor cells without damaging normal tissue cells,…

  • Delivery Method

    Research on the Application of Nanoformulation in Transdermal Drug Delivery System

    As a promising systemic drug delivery method, transdermal drug delivery system (TDDS) is easier and more convenient to operate than traditional oral, intravenous and subcutaneous injection methods. It can improve patient compliance while also avoiding First-pass effect and drug side effects. As the largest organ of the human body, the skin is also the body’s first line of defense against foreign microorganisms and chemical substances. Its drug permeability is lower, which is orders of magnitude different compared to the epithelial cells of the gastrointestinal tract and lungs. Therefore, how to pass through the many barriers of human skin is the first problem faced during transdermal drug delivery. In the past…

  • Introduction

    Application of Carrageenan Hydrogel in Biomedical Field

    Hydrogel is a three-dimensional network of hydrophilic polymers that swells in water without dissolving. Because the polymer contains a large number of hydrophilic groups, the hydrogel can absorb and lock a large amount of water. After absorbing water, the hydrogel network can maintain its original shape without being destroyed. Hydrogels are widely used in tissue engineering, drug delivery, biosensing, etc. due to their simple preparation, strong tunability of mechanical properties, good biocompatibility, and elasticity and softness that are very similar to most tissues and extracellular matrices of the human body. The field is developing rapidly. Depending on the source from which the hydrogel is prepared, hydrogels can be divided into…

  • Liposomes News

    Micelle vs Liposome

    Micelles refer to molecularly ordered aggregates that begin to form in large quantities after the surfactant concentration reaches a certain value in an aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the core of the micelle, and the hydrophilic polar groups form the outer layer of the micelle. Liposomes are an artificial membrane. In the water, the hydrophilic head of the phospholipid molecule is inserted into the water, and the hydrophobic tail of the liposome extends into the air. After stirring, a spherical liposome with a double layer of lipid molecules is formed, with a diameter ranging from 25 to 1000 nm. Micelles and liposomes…

  • Introduction

    Application of 3D Printing Bioinks Tissue Repair and Regenerative Medicine

    Introduction to 3D Printing In the 1980s, American engineer Charles Hull developed rapid prototyping technology by combining points and surfaces and then using light reinforcement. After numerous failures, he finally invented stereolithography technology. Based on this technology, the world’s The first 3D printer came into being. By the end of the 1990s, researchers combined 3D printing technology with the field of medical care to create substitutes for human organs for adjuvant treatment, which created a new field – 3D bioprinting. 3D bioprinting is a novel technology that can create structures that can combine living cells or biomaterials and control cell proliferation, differentiation, and migration on this structure. At present, 3D…

  • Liposomes News

    Lipid Nanomedicine Delivery In Vivo

    In the past few decades, the advent of lipid-based nano-delivery systems has brought research in the field of nanomedicines to new heights. Nanocarriers can encapsulate different types of drug molecules and have the advantages of improving drug solubility, extending circulation, achieving sustained and controlled drug release and targeted delivery. Lipids are important components of organisms, including fats, phospholipids, sterols, etc. Among them, phospholipids and sterols are the main components of biological membranes. Compared with other nanoformulations, lipid-based nanocarriers have good biocompatibility and complete biodegradability, low carrier toxicity and immunogenicity, and have great potential in clinical practice for the treatment of various diseases. Most of the nanomedicines currently on the market are…

  • Exosome News

    Introduction to Drug Delivery System Based on Apoptotic Body

    Extracellular vesicles are a series of membrane-structured vesicles released by cells, including exosomes, microvesicles, and apoptotic bodies. Extracellular vesicles are composed of various lipids and membrane proteins, some of which special membrane proteins help target specific tissues and cells, while others ensure that non-specific interactions are minimized, these physiological properties endow Thanks to their excellent biocompatibility and ability to target lesions, extracellular vesicles can be widely used in research in the field of drug delivery. Compared with exosomes and microvesicles produced by living cells, apoptotic bodies derived from apoptotic cells have a higher production efficiency. Apoptosis is a natural process in which cells actively package biomolecules into vesicles. Based on…

  • Introduction

    Natural Nanocarriers for Delivery Protein Drug

    Protein accounts for 18-20% of the total mass of the human body and is the main carrier of human life activity. Protein has a range of complex functions in the organism, and many human diseases are closely related to the functional regulation of protein. For example, Parkinson’s disease (PD). It is understood that protein-stable imbalance disorders associated with mitochondria are important factors that lead to PD disease. Recent studies have shown that protein / sulfur dioxide heterogeneizes can reduce endoplasmic reticulum stress and regulate unfolded protein stress signal pathway changes, which can provide neuroprotective effects in cell PD models, effectively improving Parkinson’s syndrome epithetics. Cancer is another disease closely related…