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Research Progress of PROTAC in the Treatment of Malignant Tumors
Malignant tumors are a major global public health problem, the leading cause of death in developing countries and the second leading cause of death in developed countries. Traditional treatment methods such as surgical resection, radiotherapy and chemotherapy have serious side effects on the body. Tumor immunotherapies such as small molecule inhibitors and monoclonal antibodies act on the body’s immune system to remove tumor cells and reduce the immunosuppressive signals caused by tumor cells, and achieve good clinical results. However, tumor cells are prone to gene mutations to escape immune surveillance, and small molecule inhibitors are prone to drug resistance and off-target effects. Monoclonal antibodies have large molecular weights, are difficult…
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What Are Macrocycles?
Macrocycles are generally described as molecules and ions containing twelve- or more-membered rings. Macrocyclic compounds describe a large and mature field of chemistry. The macrocycle often binds ions and facilitates the transport of ions across the hydrophobic membrane and solvent. It wraps the ions with a hydrophobic sheath, which facilitates the phase transfer characteristics. What Are Macrocyclic Effects? The macrocyclic effect is when the multidentate ligand forms a ring with the central metal atom or ion, since it is a multidentate ligand, the stability of the complex is enhanced. The macrocyclic effect is the high affinity of metal cations for macrocyclic ligands compared to their acyclic analogs. What Is a…
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What Are Chelating Agents?
Chelating agents are organic compounds capable of linking together metal ions to form complex ring-like structures called chelates. They are also known as chelants, chelators, or sequestering agents. What Are Natural Chelating Agents? Citric, malic, lactic, and tartaric acids and certain amino acids are naturally occurring chelating agents, but they are not as powerful as EDTA. The EDTA (ethylene-diamine-tetraacetic acid) molecule is a chelating agent widely used in molecular biology to sequester divalent and trivalent metal ions such as calcium and magnesium. What Is a Typical Chelating Agent? An example of a simple chelating agent is ethylenediamine. A single molecule of ethylenediamine can form two bonds to a transition-metal ion…
