In 2025, the Nobel Prize in Chemistry was awarded to Susumu Kitagawa, Richard Robson, and Omar M. Yaghi — for their pioneering work in the design and development of metal–organic frameworks. Their “molecular architectures contain rooms for chemistry,” as the Nobel Committee put it: metal ions serve as cornerstones, long organic linkers act as scaffolding, and together they assemble into crystalline networks filled with vast, tunable internal cavities. This award is more than a symbolic crowning of decades of fundamental research — it also signals that MOFs are no longer esoteric curiosities, but a foundational materials platform whose breadth of applications extends from carbon capture to energy storage, and, importantly…

Metal-organic frameworks (MOFs) form long-range ordered geometric structures through the coordination and binding of metal ions and small organic molecules, changing metal elements and small organic molecules, resulting in an ever-expanding family of MOFs. Due to their excellent properties such as low density, high specific surface area, high porosity, tunable pore size and morphology, and topological diversity, MOFs have broad application prospects in the field of drug delivery. As a drug carrier, MOFs can not only protect the drug, but also improve the human body’s absorption, release and metabolism of the drug, and enhance the therapeutic effect of the drug, which has potential advantages. Introduction to MOFs In 1995, Yaghi…