-
In Vitro Evaluation Method of Oral Nano Drug Delivery System
The in vitro evaluation method of oral nano-drug system is a simple and rapid method to evaluate the transport and absorption of oral nano-drug. This method is simple and easy to implement, has good reproducibility, and the experimental environment and conditions are easy to control, so that the influencing factors are singularized and simplified, but it cannot reflect the actual absorption state of the drug in the body. This method is often used to study the intestinal absorption mechanism of the nano drug delivery system. The method mainly includes inverted intestinal sac method, intestinal piece incubation method, membrane vesicle method, cell culture model method, parallel artificial membrane permeability determination method, computer…
-
Carrier And Biological Level Evaluation Method of Oral Nano-Drug Delivery System
The oral nano-drug system is evaluated at the body level mainly through intact animals, which have complete blood supply and innervation to ensure that the intestinal nerves are intact and directly reflect drug absorption. This evaluation method can be used to study drug penetration and absorption kinetics. The related detection methods mainly include: in vivo intestinal perfusion method, intestinal loop method, intestinal vascular intubation method and nitrogen measurement method. Intestinal Perfusion In vivo intestinal perfusion is to insert a double-lumen tube into the intestine through the mouth (in experimental animals, the perfusion tube and the drainage tube are inserted into the proximal and distal ends of the intestine respectively through…
-
New Research Develops a New X-ray Responsive Degradation Nano-drug Carrier System
Chemotherapy is a commonly used clinical treatment for tumors, but single-molecule chemotherapeutics have low bioavailability and large side effects, which could be a significant burden to patients and their families. Nanotechnology prepares single-molecule chemotherapeutic drugs into nanometer drugs, which can achieve tumor targeting and controllable release of chemotherapeutic drugs, thereby improving the therapeutic effect and reducing toxic and side effects, which is conducive to achieving high-efficiency and low-toxicity chemotherapy. Mesoporous silica nanomaterials have the advantages of simple synthesis, controllable structure, good chemical tailoring and biocompatibility, and are a nano-medicine carrier platform with good clinical application prospects. According to the characteristics of micro-acid, hypoxia and high redox in the tumor microenvironment, researchers have developed a…
-
New Nanoparticle Technology For Controlling Size And Shape—MORPH
For decades, scientists have been studying how to make better use of nanoparticles in medicine. Nanoparticles are much smaller than normal cells and are more similar in size to proteins. This makes them good at interacting with biomolecules and transporting drug molecules attached to their surface through cell membranes. However, to date, only a few nanoparticle-based drugs have successfully entered the clinic. This is because there are challenges in controlling the size and shape of nanoparticles. However, although chemists have become skilled in manipulating molecules, it is even more challenging to achieve the same level of control at the nanometer level (just raising it to one level). In particular, highly heterogeneous structures are a natural target…
-
How Can Phage Display Peptides Be Used in Nano-Drug Carriers
Nanoparticles have received extensive attention as drug carriers in the diagnosis of specific diseases, the detection and monitoring of therapeutic agents, and targeted therapies. The primary strategy for targeting drug carriers is to achieve targeting by utilizing specific recognition capabilities such as antibodies and antigens, ligands and receptors. This type of targeting is often referred to as “active targeting” by functionalizing the surface of the nanoparticle to achieve targeted behavior. Currently, researchers have developed new nanoparticle ligand drug carriers using phage display technology. The phage display technology is to clone a polypeptide or a protein coding gene or target gene fragment into a proper position of a phage coat protein…
