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How Can Phage Display Peptides Be Used in Nano-Drug Carriers
Nanoparticles have received extensive attention as drug carriers in the diagnosis of specific diseases, the detection and monitoring of therapeutic agents, and targeted therapies. The primary strategy for targeting drug carriers is to achieve targeting by utilizing specific recognition capabilities such as antibodies and antigens, ligands and receptors. This type of targeting is often referred to as “active targeting” by functionalizing the surface of the nanoparticle to achieve targeted behavior. Currently, researchers have developed new nanoparticle ligand drug carriers using phage display technology. The phage display technology is to clone a polypeptide or a protein coding gene or target gene fragment into a proper position of a phage coat protein…
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How to Achieve Brain Targeting in Nano Drug Delivery System
The blood-brain barrier (BBB) is a barrier system that exists between the blood system and the brain tissue, and is mainly composed of polarized intercellular tight junctions of polarized brain capillary endothelial cells (BCECs). It maintains a relatively stable internal environment for brain tissue, guarantees the normal physiological function of the central nervous system (CNS), and transports nutrients to the brain; but at the same time, its existence also hinders the drug of diagnosis and treatment into the brain. About 98% of small molecule drugs and almost 100% of macromolecular drugs, including proteins, peptides and gene drugs, cannot be directly delivered into the brain by peripheral administration, which is a…
