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How The Nano-Drug Delivery System Performs Brain Targeting
Brain diseases such as brain tumors, Alzheimer’s disease, Parkinson’s disease, central nervous system infections, chronic pain, drug addiction, periodic migraine, neurodegenerative diseases, epilepsy, and schizophrenia are the threat of human body and mind of improtant diseases of health. However, during the treatment process, the blood-brain barrier (BBB) prevents most drugs from entering the brain, resulting in poor drug effects. Brain targeted delivery of drugs to the brain is to use various techniques to promote the drug to break through the BBB into the brain. The current brain targeted delivery methods mainly include changing the physicochemical properties of the drug, preparing prodrugs, and carriers. Among them, nanocarriers have attracted much attention…
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How Integrin-Targeted Plaga-Chitosan Nanoparticles Are Used In Tumor Treatment
Since most chemotherapeutic drugs are toxic to normal cells, it is an important goal for cancer drug carrier development to achieve the appropriate concentration of therapeutic drugs at the location of cancer cells while reducing the exposure of normal cells to chemotherapeutic drugs. Chemotherapy is non-specific for normal cytotoxicity, mainly dose-dependent toxicity. Studies have found that targeted drug delivery systems show a higher affinity for tumor cells. Therefore, targeted nanoparticle-based drug delivery is a promising method to overcome this challenge. In lung cancer clinical studies, overexpressing receptors on cancer cell surfaces are often used as targets for therapeutic and ligand / antibody-modified nanodrug delivery vehicles. Previous studies have shown that…
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What Are The Advantages Of Nano Silver Particles In The Development Of Influenza Virus Drugs
Influenza virus is an orthomyxovirus. Its infection can cause severe respiratory diseases, which is not only a threat to human health as a result of serious individual infection or even death, but also a potential threat of rapid transmission between animals and humans, and between humans because the influenza virus can undergo frequent mutations and mutate into highly pathogenic strains. In ta huge economic he 20th century, there were several influenza pandemics in the world. All previous influenza outbreaks caused huge human and material losses to the world. Due to influenza worldwide, the number of direct deaths each year is 10,000 to 15,000, and the number of indirect deaths from…
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How Nanoparticles Promote The Development And Utilization Of Vaccines
Despite advances in conventional vaccines, improvements are still needed due to concerns about low toxicity, instability, and the need for multiple vaccination. To overcome these problems, nanotechnology has recently been incorporated into vaccine development. With the development of nanotechnology, nanotechnology is playing an increasingly important role in vaccine development, and nanocarriers provide opportunities to enhance cellular and humoral immune responses. The application of nanoparticles in vaccine formulations can not only enhance the immunogenicity and stability of the antigen, but also can target delivery and sustained release. In the past decade, nanoscale materials such as virus-like particles, liposomes, ISCOMs, polymers, inorganic nanoparticles, and emulsions have attracted attention as potential carriers of…
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Application of Protease-Responsive Nanocarriers In Near-Infrared Imaging
Cancer is one of the diseases that endanger human health. Successful diagnosis of early cancer is the key to treating and improving patient survival. Therefore, more and more research is focused on the development of dyes and drugs for cancer diagnosis and treatment. However, delivering these therapeutic (drug / dye) molecules to the site of a lesion in the body at an effective concentration is a challenge. With the research on nanotechnology, nanobiotechnology has played an important role in targeted drug application. This technology effectively improves the efficiency of therapeutic diagnostics by increasing the half-life of the molecule, maintaining effective concentrations at the target site, and reducing side effects. Recently,…
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How To Achieve Lung Targeting By Nano Drug Carrier
Due to the increasing environmental pollution and the harm of smoking, lung diseases have become an important factor affecting human health. One of the more serious diseases is lung cancer. Lung cancer is a malignant lung tumor that results from the uncontrolled growth of lung tissue cells. If left untreated, the tumor cells will metastasize to nearby tissues or elsewhere in the body. The most common primary malignant tumor of the lung is epithelial cancer, which can be roughly divided into small cell carcinoma (SCLC) and non-small cell carcinoma (NSCLC). The most common symptoms of lung cancer are cough (including hemoptysis), weight loss, shortness of breath, and chest pain. The majority (85%) of patients with lung…
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How Does The Nano-Drug Delivery System Achieve Lymphatic Targeting
Physiological characteristics of lymph The lymphatic system consists of lymphatic channels, lymphoid organs, and lymphoid tissues. Colorless and transparent lymph fluid flows in the lymph system. Lymphatic vessels include capillary lymphatic vessels, lymphatic vessels, and lymphatic ducts. Lymphatic organs include lymph nodes, thymus, and spleen. When blood flows through the capillaries, part of the liquid substance seeps into the interstitial space, forming interstitial fluid. Most are absorbed into the blood through the venous ends of the capillaries, and a small part of the water content and the interstitial fluid of macromolecules enter the capillary lymphatic vessels to become lymph. The lymph flows to the heart along the lymph vessels at…
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How The Liver-Targeted Nano-Drug Delivery System Is Realized
Physiological characteristics of the liver The liver is an important organ involved in the processes of digestion, excretion, detoxification and immunity. Liver diseases are common clinical diseases, such as viral hepatitis, cirrhosis and liver cancer, which are extremely harmful to human health. The liver-targeted drug delivery system is an important way to explore an effective treatment method for liver disease, as it enriches the drug at the site of the liver lesion to exert the curative effect, reducing the amount of drug and the number of drug administration. Liver cells are divided into hepatic parenchymal cells, Kupffer cells and endothelial cells, of which parenchymal cells are the main cells that make up the…
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How To Evaluate The Toxicology Of Nanoparticles
Nano-drug delivery systems are constantly exposed to complex physiological environments in vivo. The interaction between nano-materials, proteins and cells, their effects and possible toxicity is the key to evaluate and understand the compatibility and toxicity of nano-materials. Cell-based toxicity evaluation is the main method for the in vitro toxicity evaluation of nanometer drug delivery systems, including cell uptake and processing of nanomaterials, effects on cell signals, interference with membranes, effects on cell electron transfer beams, cytochemical factors and reactive oxygen species (ROS) production, intercellular interaction and intercellular transport, gene regulation, obvious toxic reactions, potential toxicity, and cell necrosis or apoptosis. Toxicology In Vitro Research Method Of Nano Drug Delivery System A variety of…
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How To Measure The Efficiency Of Drug Packaging?
The encapsulation efficiency is an important parameter of the nanodrugs delivery system and can be calculated by the following formula: Encapsulation efficiency (%) = Weight of the drug in nanoparticles / (Weight of the drug in nanoparticles +Weight of the drug in medium) X100% There are generally two methods for determining the drug encapsulation efficiency in a nanometer drug delivery system: 1) the free drug is separated from the nanocarrier and measured; 2) the free drug and the nanocarrier are not separated and measured directly. The first method requires the encapsulated drug to be stable and it should has no leakage during separation. The separation methods include dialysis, gel column chromatography, high speed centrifugation, centrifugal ultrafiltration and microcolumn centrifugation.…
