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What Is Zeta Potential?
Zeta potential is a specialized term for kinetic potential in colloidal dispersions, also called electromotive potential (ζ-potential), which is used to characterize the surface potential of nanoparticles. Theoretically, zeta potential is the potential of the sliding surface in the interface bilayer relative to a point in the fluid far from the interface. In other words, zeta potential is the potential difference between the dispersion medium and the fluid-fixed layer attached to the dispersed particles. The potential is caused by the net charge in the area around the sliding plane and also depends on the position of the sliding plane. The higher the Zeta potential (positive or negative), the greater the…
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New Nanoparticle Technology For Controlling Size And Shape—MORPH
For decades, scientists have been studying how to make better use of nanoparticles in medicine. Nanoparticles are much smaller than normal cells and are more similar in size to proteins. This makes them good at interacting with biomolecules and transporting drug molecules attached to their surface through cell membranes. However, to date, only a few nanoparticle-based drugs have successfully entered the clinic. This is because there are challenges in controlling the size and shape of nanoparticles. However, although chemists have become skilled in manipulating molecules, it is even more challenging to achieve the same level of control at the nanometer level (just raising it to one level). In particular, highly heterogeneous structures are a natural target…
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What Is The Basic Principle Of Nano-Targeting
After administration of a common pharmaceutical preparation, it is usually freely distributed in the body and then taken up by cells and organs. Due to the existence of various biological barriers in the body, such as the blood-brain barrier and the blood-retinal barrier, only a small part of the drug reaches the target site. The targeted preparation can selectively concentrate the drug on the lesion by means of the nanocarrier, and the lesion can be a target tissue, a target organ, or a target cell or a target in the cell. According to the arrival location of the drug, the targeting can be divided into three levels: the first level refers…
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What Is Drug Controlled Release Nanotechnology
The positioning, timing and constant release of pharmaceutical preparations have always been the focus of pharmaceutics research. Special drug delivery systems are prepared by a variety of physical, chemical, and biological methods to control drug release behavior, release the drug at a fixed site of the organism, release it within a predetermined time, or release at a predetermined rate. Compared with common preparations, the controlled release drug delivery system has the advantages of less administration times, stable blood concentration, less drug irritation, and high bioavailability of the drug. Nanotechnology is used to prepare drug carriers by embedding, encapsulating, adsorbing or chemically binding the nanocarrier system. Specific carrier types include nanoparticles,…
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How To Modify The Surface Of Nanoparticles
After the material is micro-nanosized, especially in the nano-state, its size is between atoms, molecules and bulk materials, so it is called the fourth state of matter. As nanoparticles have many special properties, people have shown great enthusiasm for the research of nanomaterials. They have synthesized a variety of nano- and nano-composites with advanced functions and outstanding performance, which are widely used in various fields. The fine particle size, large specific surface area, insufficient atomic coordination and high surface energy of the nanoparticles make these surface atoms highly active, extremely unstable, and easy to agglomerate. This agglomerated secondary particles are difficult to exert their nano-effects, making the material less than…
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Nanoparticle Delivery Technology Crispr-Gold Helps Crispr Treatment of Autism
CRISPR is a repeating sequence in the prokaryotic genome. It is an immune weapon produced by the struggle between bacteria and viruses in the history of life evolution. Simply put, the virus can integrate its own genes into the bacterial genome and use the bacterial cell tools for its own the gene duplication service. In order to remove the foreign invading genes of the virus, Bacteria evolved the CRISPR-Cas9 system. With this system, bacteria can quietly remove the virus gene from its own chromosome, which is the unique immune system of bacteria. Microbiologists have mastered the immune function of bacteria with a variety of excised foreign virus genes. The more…
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Injectable Hydrogel
Hydrogels are gels in which water is the dispersion medium. The water-soluble polymer having a network cross-linking structure introduces a part of a hydrophobic group and a hydrophilic residue, and the hydrophilic residue is combined with a water molecule to connect the water molecule inside the network, and the hydrophobic residue expands with water. Hydrogels are well suited for a wide range of applications due to their high water content and the regulated mechanical properties. Studies have found that many hydrogel systems can form strong, tough and elastic covalently crosslinked hydrogel materials by covalent cross-linking methods, including light, temperature and pH-induced free radical processes. However, they may also Limited by…
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Application of Iron Oxide Nanoparticles in Tumor Imaging and Treatment
Magnetic nanoparticles have received great attention in various fields due to their unique physicochemical properties and wide application potential.In the past decade, the synthesis and application of magnetic nanoparticles from the bottom up has been a hot topic in the field of chemistry, chemical engineering, materials science and biomedicine. High-quality magnetic nanoparticles can be synthesized by chemical methods such as coprecipitation, high temperature thermal decomposition, and sol-gel methods. Compared to the top-down synthesis method, the bottom-up synthesis method can synthesize nanoparticles with uniform particle size and can be widely used in various fields: data storage, catalysts, biological separation and biosensing. A typical magnetic nanoparticle is synthesized by a bottom-up method comprising…
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Research Progress of Mesoporous Silica in Drug Delivery Systems
In recent years, the development of nanotechnology has brought about the dawn of overcoming many problems of traditional clinical drugs such as low solubility, weak selectivity, biodistribution and poor pharmacokinetics. Currently, a variety of nanomaterials such as silica, liposomes, carbon materials, layered hydroxides, and polymers have been reported as carriers for drug delivery. However, these new drug delivery systems still have many defects. For example, direct mixing of the silica sol and the drug results in heterogeneous dispersion of the drug, thereby causing the drug release rate to be affected by the sample batch. Liposomal carriers are less stable and are easily cleared by the reticuloendothelial system, resulting in fewer…
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Nanoparticle Drug Delivery De-immunization Study
The human immune system can recognize and destroy foreign objects. In addition to bacteria and viruses, drug-delivering nanoparticles, implanted pacemakers, and artificial joints, which are also foreign, also trigger an immune response that causes drug failure, rejection, or inflammation. To this end, scientists at the University of Pennsylvania have developed a new method of attaching protein “passports” to these therapeutic devices so that they can pass through the body’s defense system. The body will reject the invading foreign objects without discrimination, which is caused by the body’s natural immune system. This process involves a variety of cells, such as macrophages, which can detect, swallow and destroy invaders; serum proteins will…
