Excipients for mRNA Delivery
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The active ingredients of mRNA vaccines are usually encapsulated in lipid nanoparticles (LNPs) to protect mRNA from degradation and efficiently complete the intracellular delivery of mRNA. Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics.
CD Bioparticles is a leading supplier of LNP delivery materials, providing customers with various high-quality lipid excipients (mRNA delivery system excipients). Our facility is ISO9001 and ISO13485 certified and manufactures products at scale for global customers according to ICH Q7A guidelines. At present, we have a variety of nucleic acid delivery excipients with independent intellectual property rights, and can customize the production according to customer requirements. Many of our products (including customized structures) have been verified by many mRNA vaccine manufacturers and widely recognized by our customers.
Today we offer you:
Right excipient and lipids, which are essential for successful encapsulation.
- Manufacturing of pharmaceutical excipients
- Cationic lipids encapsulating negatively charged mRNA
- PEGylated lipids contribute to the formation of a protective hydrophilic layer, thereby sterically stabilizing LNP
- Custom and portfolio lipids options for the different types of lipids you need to create stable LNPs and protect the mRNA
Excipients for mRNA Delivery
| Product Name |
CAS No. |
Structural Formula |
| mPEG-CM, 2000Da |
9004-74-4 |
|
| mPEG-OH, 2000Da |
67665-18-3 |
|
| mPEG-DPPE |
205494-72-0 |
|
| mPEG-DSPE |
147867-65-0 |
|
| mPEG-DMG |
160743-62-4 |
|
| ALC-0159 mPEG-DTA |
1849616-42-7 |
|
| ALC-0315 DHA |
2036272-55-4 |
|
| SM-102 HUO |
2089251-47-6 |
|
| D-Lin-MC3-DMA |
1224606-06-7 |
|
| DSPC |
816-94-4 |
|
| DOTMA |
104872-42-6 |
|
Excipients for mRNA Delivery
| Product Name |
CAS No. |
Structural Formula |
| DOSPA |
168479-03-6 |
|
| DOTAP |
132172-61-3 |
|
| ePC |
1246304-44-8 |
|
| DLin-MC3-DMA |
1224606-06-7 |
|
| C12-200 |
1220890-25-4 |
|
| ALC-0315 |
2036272-55-4 |
|
| cKK-E12 |
1432494-65-9 |
|
| 306Oi10 |
2322290-93-5 |
|
| 2322290-93-5 |
2490668-30-7 |
|
| TT3 |
1821214-50-9 |
|
| 9A1P9 |
2760467-57-8 |
|
Excipients for mRNA Delivery
| Product Name |
CAS No. |
Structural Formula |
| FTT5 |
2328129-27-5 |
|
| DOPE |
4004-05-1 |
|
| Cholesterol |
57-88-5 |
|
| DC-Cholesterol |
137056-72-5 |
|
| β-sitosterol |
5779-62-4 |
|
| BHEM-Cholesterol |
624742-83-2 |
|
| DDAB |
3700-67-2 |
|