PEG Conjugations


CD Bioparticles’ products with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

  • Strong immune response or foreign body response of your materials
  • Fibrosis and fibrous encapsulation of your drug delivery materials
  • Fast clearance of your drug cargos
  • Limited PEGylation methods on your materials

Key Features

  • Lipid PEGs
    • Diversified functional groups for various applications; Enhanced lipophilic properties for small and macromolecule formulations; Customized size and functionalities
  • Y-Shaped PEGs
    • The sterically bulky structure of Y-shape branched PEG derivatives, consisting of two linear methoxy PEG chains attached to a central core with an active NHS group, may help to reduce the number of attachment sites to a protein molecule and enable simple and efficient modification of proteins and other biological agents that contain lysines.
  • Trifunctional PEGs
    • Designed as linkers for Antibody-Drug Conjugates (ADCs), as they facilitate the coupling of high ratios of drug molecule per antibody. ADCs conjugated via multi-arm PEGs deliver a higher concentration of drugs to targets for each antibody-antigen interaction and exhibit improved solubility and PK/PD profile.
  • Monodispersed Linear PEGs
    • PEG oligomers with monodispersed molecular weight distribution for your precise synthesis and conjugation.
  • Monofunctional Linear PEGs
    • Multi-arm monofunctional
  • Monofunctional Linear PEGs
    • Multi-arm monofunctional
  • Homobifunctional Linear PEGs
    • Choices of Diacrylate, Dimethacrylate, Divinylsulfone; Dialkyne, Diazide; Dithiol, Dimaleimide; Diepoxy; Dibiotin; Diamine; Diisocyanate; Dialdehyde; Disuccinimidyl carbonate; Disilane; Dicarboxylic acid, Diglutaric acid, Diglutamidyl acid; DiIodoacetyl, Bis(nitrophenyl carbonate), orthopyridyl disulfide, Dihydroxyl for your customized crosslinking and conjugation
  • Heterobifunctional Linear PEGs
    • Various of combination of two different functional groups at PEG terminals
    • Multi-arm heterobifunctional PEG derivatives for antibody-drug conjugation (ADCs) as regular products or through custom synthesis. ADCs conjugated via multi-arm PEGs deliver a higher concentration of drugs to targets for each antibody-antigen interaction and exhibit improved solubility and PK/PD profile
  • 2-Arm PEGs
    • Multi-arm PEG derivatives useful for hydrogel crosslinking and surface coating
  • 4-Arm PEGs
    • Multi-arm PEG derivatives useful for hydrogel crosslinking and surface coating
  • 8-Arm PEGs
    • Multi-arm PEG derivatives useful for hydrogel crosslinking and surface coating

Key benefits:

  • Wide coverage of functional groups useful for different conjugation/crosslinking reactions
  • Various of density of the functional groups or different chemical geometries useful for fabricating biomaterials with controllable mechanical properties
  • Active building blocks for different biomaterial fabrications
  • From non-GMP small laboratory scale, to commercial scale in GMP and non-GMP grade

Application candidates:

  • Biomaterials (i.e. hydrogels) with non-immune response
  • Non-fibrosis surface coating applications
  • Antibacterial applications
  • Nanomaterial modifications for long-term circulation purpose

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