PEG Conjugations

CD Bioparticles’ products with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Strong immune response or foreign body response of your materials
• Fibrosis and fibrous encapsulation of your drug delivery materials
• Fast clearance of your drug cargos
• Limited PEGylation methods on your materials

Key Features

• Lipid PEGs
  • Diversified functional groups for various applications; Enhanced lipophilic properties for small and macromolecule formulations; Customized size and functionalities
• Y-Shaped PEGs
  • The sterically bulky structure of Y-shape branched PEG derivatives, consisting of two linear methoxy PEG chains attached to a central core with an active NHS group, may help to reduce the number of attachment sites to a protein molecule and enable simple and efficient modification of proteins and other biological agents that contain lysines.
• Trifunctional PEGs
  • Designed as linkers for Antibody-Drug Conjugates (ADCs), as they facilitate the coupling of high ratios of drug molecule per antibody. ADCs conjugated via multi-arm PEGs deliver a higher concentration of drugs to targets for each antibody-antigen interaction and exhibit improved solubility and PK/PD profile.
• Monodispersed Linear PEGs
  • PEG oligomers with monodispersed molecular weight distribution for your precise synthesis and conjugation.
• Monofunctional Linear PEGs
  • Multi-arm monofunctional
• Monofunctional Linear PEGs
  • Multi-arm monofunctional
• Homobifunctional Linear PEGs
  • Choices of Diacrylate, Dimethacrylate, Divinylsulfone; Dialkyne, Diazide; Dithiol, Dimaleimide; Diepoxy; Dibiotin; Diamine; Diisocyanate; Dialdehyde; Disuccinimidyl carbonate; Disilane; Dicarboxylic acid, Diglutaric acid, Diglutamidyl acid; DiIodoacetyl, Bis(nitrophenyl carbonate), orthopyridyl disulfide, Dihydroxyl for your customized crosslinking and conjugation

• Heterobifunctional Linear PEGs
  • Various of combination of two different functional groups at PEG terminals
  • Multi-arm heterobifunctional PEG derivatives for antibody-drug conjugation (ADCs) as regular products or through custom synthesis. ADCs conjugated via multi-arm PEGs deliver a higher concentration of drugs to targets for each antibody-antigen interaction and exhibit improved solubility and PK/PD profile
• 2-Arm PEGs
  • Multi-arm PEG derivatives useful for hydrogel crosslinking and surface coating
• 4-Arm PEGs
  • Multi-arm PEG derivatives useful for hydrogel crosslinking and surface coating
• 8-Arm PEGs
  • Multi-arm PEG derivatives useful for hydrogel crosslinking and surface coating

Key benefits:

• Wide coverage of functional groups useful for different conjugation/crosslinking reactions
• Various of density of the functional groups or different chemical geometries useful for fabricating biomaterials with controllable mechanical properties
• Active building blocks for different biomaterial fabrications
• From non-GMP small laboratory scale, to commercial scale in GMP and non-GMP grade

Application candidates:

• Biomaterials (i.e. hydrogels) with non-immune response
• Non-fibrosis surface coating applications
• Antibacterial applications
• Nanomaterial modifications for long-term circulation purpose