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Ligands for Target Protein for PROTAC


Specialized compounds known as PROTAC (PROteolysis TArgeting Chimeras) ligands are intended to break down particular proteins in cells. These molecules are made up of two crucial parts: an E3 ubiquitin ligase recruiter and a ligand that binds to the target protein. Selectivity is ensured by carefully selecting the ligand that binds to the target protein to fit a particular pocket or binding site on the protein's surface. The other ligand attracts an E3 ubiquitin ligase, an enzyme in charge of ubiquitin-tagging proteins. Ubiquitin molecules are bound to the target protein, designating it for breakdown, when the PROTAC molecule brings the target protein and the E3 ligase close together. The cell's proteasome machinery recognizes the ubiquitinated protein and breaks it down, effectively removing it from the cellular environment. This targeted protein degradation approach shows promise in drug discovery and the development of new therapeutic strategies.

CD Bioparticles manufactures and supplies ligands for target protein for PROTAC research. Contact us to find out how ligands for target protein can help your work.

Ligands for Target Protein for PROTAC

DUPA

Catalog: CDMDC11

MW: 320.25

Ligands for Target Protein for PROTAC

Ibrutinib

Catalog: CDMDC01

MW: 440.5

Ligands for Target Protein for PROTAC

(+)-JQ-1

Catalog: CDMDC02

MW: 456.99

Ligands for Target Protein for PROTAC

Quizartinib

Catalog: CDMDC03

MW: 560.67

Ligands for Target Protein for PROTAC

SI-109

Catalog: CDMDC04

MW: 835.79

Ligands for Target Protein for PROTAC

CCR7 Ligand 1

Catalog: CDMDC05

MW: 320.25

Ligands for Target Protein for PROTAC

Tazemetostat de(methyl morpholine)-COOH

Catalog: CDMDC06

MW: 517.62

Ligands for Target Protein for PROTAC

PROTAC PARP/EGFR ligand 1

Catalog: CDMDC07

MW: 1020.52

Ligands for Target Protein for PROTAC

BMS-37

Catalog: CDMDC08

MW: 448.55

Ligands for Target Protein for PROTAC

SLF TFA

Catalog: CDMDC09

MW: 638.67

Ligands for Target Protein for PROTAC

SLF

Catalog: CDMDC10

MW: 524.65

Ligands for Target Protein for PROTAC

Navitoclax-piperazine

Catalog: CDMDC13

MW: 973.63

Ligands for Target Protein for PROTAC

AP1867-2-(carboxymethoxy)

Catalog: CDMDC14

MW: 693.78

Ligands for Target Protein for PROTAC

SLF-amido-C2-COOH

Catalog: CDMDC16

MW: 624.72

Ligands for Target Protein for PROTAC

BI-4464

Catalog: CDMDC17

MW: 555.55

Ligands for Target Protein for PROTAC

N-piperidine Ibrutinib hydrochloride

Catalog: CDMDC18

MW: 422.91

Ligands for Target Protein for PROTAC

I-BET762 carboxylic acid

Catalog: CDMDC19

MW: 396.83

Ligands for Target Protein for PROTAC

CBP/p300 ligand 2

Catalog: CDMDC20

MW: 524.61

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