Cleavable Peptide Linkers

Peptide linkers are a class of protease cleavable linkers. Peptide linkers are key components of antibody drug conjugates (ADCs) due to their superior plasma stability and controlled load release mechanism. Well-designed linkers help antibodies selectively deliver cytotoxic drugs to tumor cells and deliver drugs accurately at tumor sites. By introducing PEG into the linker, it increases the water solubility of the linker itself and helps fine-tune the drug DMPK.

CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:

The challenges you might meet:

• Drugs have a shorter circulation time in the blood
• The concentration of the drug at the tumor site is not sufficient
• Linkers are unable to lyse rapidly in target tumor tissue causing toxic accumulation
• Instability of linkers causes damage to normal tissue cells
• The immunogenicity of linkers affects the efficacy of target drugs
• Antibodies can form heterogeneous mixtures through conjugates with drugs, leading to complex pharmacokinetics

Key benefits:

• Low immunogenicity, able to penetrate the blood-brain barrier
• High tumor affinity and specificity
• PEGylated cleavable lipid improves in vitro transfection efficiency of RTNs
• Long PEG chains increase drug release and enhance anticancer activity of drugs
• Reduce the steric hindrance of the payload
• Increase the hydrophilicity of the loaded drugs
• High bioavailability and biocompatibility
• Rupture resistance and specific cracking conditions
• Suitable for in vitro and in vivo experiments
• Ready-to-use

Application candidates:

• Treatment of tumor
• Construction and application of peptide-drug conjugates (PDCs)
• Investigate the role of linker chemistry in enhancing drug efficacy, increasing cycle time and reducing toxicity
• Protein labeling