CD Bioparticles provides custom services for Nanostructured Lipid Carriers (NLCs) formulation design and drug encapsulation. Together with advanced preparation technologies for various liposomes, scientists in CD Bioparticles are proficient in producing NLCs for various types of drug loading, especially for the chemical drugs. We can provide the service of formulation design depending on the application, drug encapsulation, physical and chemical properties, in vitro and in vivo characterization according to customer's project needs.
Nanostructured lipid carriers are composed of a variety of liquid lipids(LL), solid lipids(SL), and surfactants mixed in specific ratios and dispersed in aqueous solutions.
The ingredients common used in formulation of NLCs:
Therefore, they have a solid matrix at room temperature and are considered superior to many other traditional lipid-based nanocarriers such as nanoemulsions, liposomes and solid lipid nanoparticles (SLNs)[1]. The structure difference of NLC and other lipid-based nanoparticles are shown in Figure 1.
Figure 1. Different types of lipid-based nanoparticles. (A) Nanoemulsions; (B) Liposomes; (C) Solid lipid nanoparticles (SLNs); and (D) Nanostructured lipid carriers (NLCs). Solid lipids (SL), liquid lipids (LL)
The specific features of NLCs include:
The applications of NLCs include:
NLCs were broadly studied as delivery systems for a variety of therapeutic and cosmetic applications for parenteral, topical, oral, ophthalmic, and pulmonary administration for management of central nervous system diseases, inflammatory diseases, skin conditions, bacterial and fungal infection, as well as the administration of local anesthetics[3].
Our Featured Services
LNPs formulation design: we customize LNPs design based on our clients' demand by varying lipid structure (both commercials and clients new developed), lipid compositions, vesicle sizes, surface charges, etc.
LNPs encapsulation: we employ customized protocols to encapsulate drug molecules into LNPs by several different methods with high encapsulation efficiency.
LNPs-drug complex analysis: we can offer comprehensive analysis assays for LNPs before and after encapsulation, which includes visual appearance, size distribution, stability, zeta potential, lamellarity, entrapment efficiency, and release rate.
LNPs-drug biological activity characterization: we can control and analysis the cell uptake efficiency and the cytotoxicity by the lipid structure, charge ratio,etc.
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