Anti-Nucleolin Aptamer Synthesis and Modification Service

Nucleophosmin aptamers can specifically recognize and bind cell surface protein receptors through a unique three-dimensional structure, and even undergo intracellular cation, making them functionally comparable to, and more advantageous than, conventional antibodies.

CD Bioparticles offers nucleophosmin aptamer synthesis and modification services. We use the synthesis and modification of aptamers to provide a reference for studying the role of aptamers in cancer drug delivery. We are able to exploit the unique advantages of nucleophosmin aptamers for targeted diagnosis and treatment of diseases.

Introduction to Anti-Nucleoporin Aptamers

Nucleophosmin is a predominantly nuclear and cytoplasmic phosphoprotein that is thought to play a key role in different biological processes. In addition to its nuclear and cytoplasmic localization, nucleolin is present on its cell surface. Many tumor cells and neovascular endothelial cells express nucleolin highly on their surface, and expression of nucleolin on the cell surface is associated with cell proliferation.

Changes in the subcellular localization and expression of nucleolin directly reflect the pathological state and process of tumorigenesis and development. Changes in nucleolin distribution may be an early sign of proliferative carcinogenesis. Under normal circumstances, nucleolin is mainly found in the nucleus, whereas the extranuclear expression of nucleolin is closely related to tumourigenesis, metastasis, and poor overall survival. Therefore, functional blockade of nucleolin on the cell surface represents a potential target for the development of anti-cancer therapies.

Nucleic acid aptamers specifically bind to nucleolin to prevent the repair of DNA damage, promote apoptosis and deliver drugs from the cell surface to the nucleus for active targeting.

Fig. 1 Schematic structure of nucleolin with acidic stretches on N-terminal, nuclear localization signal (NLS), RNA-binding domains in the central region and glycine and arginine rich (GAR) domains in the C-terminus, and their related major functions or properties. (Carvalho LS, et al., 2021)

Our Anti-Nucleolin Aptamer Services

CD Bioparticles provides aptamer synthesis and modification services for anti-nucleoporins. Our experienced scientists will screen your aptamer synthesis and aptamer modification.

Our team offers services from the construction of aptamers to the modification of aptamers for the study of targeted drug delivery systems. We can also customize other aptamer types to suit your needs.

Our service process focuses on but is not limited to, the following:

• Screening for aptamers that can target nucleoporin proteins

• Synthesis and purification of anti-nucleoporin aptamers

• Specificity and affinity analysis

Advantages of Our Anti-Nucleolin Services

• In contrast to nucleophosmin ligands such as peptides, pseudo peptides, and recombinant immune preparations, the greatest advantages of nucleophosmin aptamers are Stability and low immunogenicity
• The ease of synthesis and modification makes them more promising for clinical applications.
• Nucleic acid aptamers can specifically recognize and bind to their homologous targets through their unique three-dimensional structure, and even undergo intracellular cation, making them functionally comparable to traditional antibodies, but with additional advantages over them.

Contact Us

CD Bioparticles offers services for the synthesis and modification of anti-nucleophosmin aptamers. We have developed a wide range of aptamers that bind to cell surface receptors, exploiting the unique advantages of nucleophosmin aptamers for targeted disease diagnosis and treatment. If you are interested in our services, please do not hesitate to contact us.

Quotations and Ordering

Reference

1. Carvalho LS, Gonçalves N, Fonseca NA, et al. Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis. Pharmaceuticals (Basel). 2021; 14 (1)