Chondroitin sulfate (CS) is a kind of important acidic macromolecular viscous polysaccharide derived from animal laryngeal, nasal cartilage, trachea and other cartilage-rich tissues, and has a variety of important biological activities. Chondroitin sulfate is composed of D-glucuronic acid and A disaccharide polymer composed of alternately linked hexosamines. It usually exists in the form of glycoprotein combined with protein. When it is hydrolyzed, a β-elimination reaction occurs, so that the sugar-peptide bond connecting the O-glycosidic bond of chondroitin sulfate and protein is broken, releasing free chondroitin sulfate. The hydroxyamino acids attached to the O-glycosidic bonds were converted to the corresponding keto acids, respectively. Existing studies have shown that chondroitin sulfate has a good effect as a treatment drug for rheumatism, arthritis, frozen shoulder, low back pain, neuralgia, migraine, etc.. In addition, chondroitin sulfate has a variety of other pharmacological activities, including reducing vitreous-retina adhesion, preserving cornea and treating corneal injury, anti-tumor, degrading mucus in cystic fibrosis sites, promoting regeneration of nerve axis and strengthening chondrocytes Adhesion to cartilage, etc.. It can be used for the development of new drugs.
CD Bioparticles offers chondroitin sulfates of various molecular weights for drug discovery research. In addition, we also offer chondroitin sulfates modified with biotin and thiol groups. Contact us to learn how chondroitin sulfates can help your work.