Hyaluronic acid (HA) is a natural glycosaminoglycan, which is formed by the repeated connection of the disaccharide units of glucuronic acid and N-acetylglucosamine. HA has good biocompatibility, excellent degradability, rich functional motifs, and easy chemical modification. The nano-drug delivery carrier prepared by grafting functional units can well maintain the activity of polypeptides, proteins, gene and other substances during the delivery process. In addition, HA can also prolong the half-life of the drug in the body, increase the water solubility of the drug, maintain the activity of some peptides and other molecules, and improve the pharmacokinetic characteristics, etc. This makes the drug treatment efficiency greatly improved. Due to the excellent biocompatibility, biodegradability, and tumor targeting of HA, HA-based nanoassemblies have great advantages in stable drug delivery and active targeting of cancer cells.
CD Bioparticles offers hyaluronic acid polymers of varying molecular weights for drug discovery research. In addition, we also offer hyaluronic acid polymers modified with aldehyde, amine, azide, biotin, hydrazide, lipid, maleimide, methacrylate, NHS, PEG, thiol, and tyramine groups.