Peptide linkers are a class of protease cleavable linkers. Peptide linkers are key components of antibody drug conjugates (ADCs) due to their superior plasma stability and controlled load release mechanism. Well-designed linkers help antibodies selectively deliver cytotoxic drugs to tumor cells and deliver drugs accurately at tumor sites. By introducing PEG into the linker, it increases the water solubility of the linker itself and helps fine-tune the drug DMPK.
CD Bioparticles' services with customized delivery strategies, precise designs and modifications of drugs or drug-contained cargos, and advanced technical platforms can help you to solve:
The challenges you might meet:
Drugs have a shorter circulation time in the blood
The concentration of the drug at the tumor site is not sufficient
Linkers are unable to lyse rapidly in target tumor tissue causing toxic accumulation
Instability of linkers causes damage to normal tissue cells
The immunogenicity of linkers affects the efficacy of target drugs
Antibodies can form heterogeneous mixtures through conjugates with drugs, leading to complex pharmacokinetics
Cleavable Peptide Linkers Key benefits:
Low immunogenicity, able to penetrate the blood-brain barrier
High tumor affinity and specificity
PEGylated cleavable lipid improves in vitro transfection efficiency of RTNs
Long PEG chains increase drug release and enhance anticancer activity of drugs
Reduce the steric hindrance of the payload
Increase the hydrophilicity of the loaded drugs
High bioavailability and biocompatibility
Rupture resistance and specific cracking conditions
Suitable for in vitro and in vivo experiments
Ready-to-use
Cleavable Peptide Linkers Application candidates:
Treatment of tumor
Construction and application of peptide-drug conjugates (PDCs)
Investigate the role of linker chemistry in enhancing drug efficacy, increasing cycle time and reducing toxicity