Covalent Organic Frameworks: Recent Progress in Biomedical Applications

Shi, YQ; Gao, F; Zhang, QC; Yang, JL

Abstract

Covalent organic frameworks (COFs) are a type of crystalline organic porous material with specific features and interesting structures, including porosity, large surface area, and biocompatibility. These features enable COFs to be considered as excellent candidates for applications in various fields. Recently, COFs have been widely demonstrated as promising materials for biomedical applications because of their excellent physicochemical properties and ultrathin structures. In this review, we cover the recent progress of COF materials for applications in photodynamic therapy, gene delivery, photothermal therapy, drug delivery, bioimaging, biosensing, and combined therapies. Moreover, the critical challenges and further perspectives with regards to COFs for future biology-facing applications are also discussed.

Keywords: covalent organic frameworks; drug delivery; gene delivery; biosensing; bioimaging; biomedical applications; biocompatibility; photodynamic thermal treatment

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Covalent Organic Framework (COF) Materials

Covalent organic frameworks (COFs) have shown excellent application potential in the biomedical field. The highly ordered structure and tunability of COF make it an ideal platform for various biomedical applications. In terms of drug delivery, COF can be used as a carrier to achieve efficient loading and controlled release of drugs, improving therapeutic effects. In addition, the surface of COF can be customized and used to construct biosensors to achieve highly sensitive detection of biomolecules and contribute to early diagnosis of diseases. COFs also play a role in tissue engineering by providing a scaffold structure to promote cell growth and tissue repair. Overall, the unique properties of COFs make them an important component of innovative biomedical technologies, bringing new possibilities in areas such as treatment, diagnosis, and tissue repair.