Clipos™ Gilteritinib (ASP2215) Encapsulated Liposomes


Catalog:CDEPG-19

Unit Size:2 mL, 10 mL

INQUIRY Datasheet

Specifications
Description Gilteritinib (ASP2215) is a small-molecule inhibitor of FLT3/AXL with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. Gilteritinib (ASP2215) is a highly selective FLT3 inhibitor that demonstrates activity against both FLT3-ITD and FLT3-TKD mutation subtypes and selectively inhibits FLT3 at concentrations roughly 800-fold lower than those required to inhibit c-Kit (230 nM). This product is a pre-formulated liposomal version of Gilteritinib (ASP2215) which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance; the lipid composition of the liposomes is the same as Doxil. For preclinical research use only.
Lipid composition HSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3 molar ratio)
Liposome Size 70-120 nm
Lipid Molar Concentration 26.4 mM
Encapsulated Drug Gilteritinib
Drug concentration 2.5 mg/mL
Inside Buffer 250 mM ammonium sulfate, pH 5.5
Outside Buffer DPBS (1X), pH 7.4
Storage 2 °C to 8 °C (do not freeze), stored under nitrogen
Shelf-life At least 3 months
CAS No. 1254053-43-4
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