Clipos™ Lxabepilone (BMS-247550) Encapsulated Liposomes


Catalog:CDEPG-20

Unit Size:1 mg, 5 mg, 10 mg

INQUIRY Datasheet

Specifications
Description PEGylated liposomes containing Ixabepilone (BMS-247550). Ixabepilone is a semi-synthetic analog of epothilone B which binds tubulin and promotes tubulin polymerization and microtubule stabilization, causing cell cycle arrest in the G2-M phase and inducing tumor cell apoptosis. Compared to taxanes, epothilones have higher affinity for β-tubulin and are not P-gp substrates. Thus, Ixabepilone can inhibit growth of tumor cells which are resistant to taxanes and/or anthracyclines due to increased P-gp. This product is a pre-formulated liposomal version of Ixabepilone which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
Lipid composition PEGylated Liposomes
Liposome Size 70-120 nm
Lipid Molar Concentration 60 mM
Encapsulated Drug Ixabepilone
Drug concentration 2.5 mg/mL (± ~5%)
Inside Buffer 292 mM sucrose, 0.5% DPBS (1X)
Outside Buffer 292 mM sucrose, 0.5% DPBS (1X)
Storage 2 °C to 8 °C (do not freeze), protect from light
Shelf-life At least 1 month
CAS No. 219989-84-1
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